McNamara, H. C., Wood, R., Chalmers, J., Marlow, N., Norrie, J., MacLennan, G., McPherson, G., Boachie, C. and Norman, J. E. (2015) STOPPIT baby follow-up study: the effect of prophylactic progesterone in twin pregnancy on childhood outcome. PLoS ONE, 10(4), e0122341. (doi: 10.1371/journal.pone.0122341) (PMID:25881289) (PMCID:PMC4400139)
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Abstract
Objectives To determine the long-term effects of in utero progesterone exposure in twin children.
Methods This study evaluated the health and developmental outcomes of all surviving children born to mothers who participated in a double-blind, placebo-controlled trial of progesterone given for the prevention of preterm birth in twin pregnancies (STOPPIT, ISRCTN35782581). Follow-up was performed via record linkage and two parent-completed validated questionnaires, the Child Development Inventory and the Health Utilities Index. Results Record linkage was successfully performed on at least one record in 759/781 (97%) children eligible for follow-up. There were no differences between progesterone-exposed and placebo-exposed twins with respect to incidence of death, congenital anomalies and hospitalisation, nor on routine national child health assessments. Questionnaire responses were received for 324/738 (44%) children. The mean age at questionnaire follow-up was 55.5 months. Delay in at least one developmental domain on the Child Development Inventory was observed in 107/324 (33%) children, with no evidence of difference between progesterone-exposed and placebo-exposed twins. There was no evidence of difference between the progesterone and placebo groups in global health status assessed using the Health Utilities Index: 89% of children were rated as having ‘excellent’ health and a further 8% as having ‘very good’ health. Conclusions In this cohort of twin children there was no evidence of a detrimental or beneficial impact on health and developmental outcomes at three to six years of age due to in utero exposure to progesterone.Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Boachie, Mr Charles |
Authors: | McNamara, H. C., Wood, R., Chalmers, J., Marlow, N., Norrie, J., MacLennan, G., McPherson, G., Boachie, C., and Norman, J. E. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
Journal Name: | PLoS ONE |
Publisher: | Public Library of Science |
ISSN: | 1932-6203 |
ISSN (Online): | 1932-6203 |
Copyright Holders: | Copyright © 2015 The Authors |
First Published: | First published in PLoS ONE 10(4):e0122341 |
Publisher Policy: | Reproduced under a Creative Commons License |
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