Ma, Y., Faller, W., Sansom, O. , Brown, E. R., Doig, T. N., Melton, D. W. and Machesky, L. (2015) Fascin expression is increased in metastatic lesions but does not correlate with progression nor outcome in melanoma. Melanoma Research, 25(2), pp. 169-172. (doi: 10.1097/CMR.0000000000000135) (PMID:25535872)
Full text not currently available from Enlighten.
Publisher's URL: http://dx.doi.org/10.1097/CMR.0000000000000135
Abstract
Levels of the actin bundling protein fascin correlate with invasion and metastasis and reveal prognostic value in many epithelial carcinomas. However, we know very little about the potential role of fascin in melanoma. The purpose of this study is to compare fascin expression in primary melanomas and melanoma metastasis. Fascin expression was examined through the immunohistochemistry of paraffin embedded tissue microarrays including 560 cores of primary tumour and metastasis. Fascin expression was significantly elevated in 48 metastases compared with 254 primary tumours (P =0.034). In 187 patients with primary melanomas, fascin was not correlated with survival (P= 0.067), whereas low fascin was significantly correlated with the presence of ulceration (P = 0.005). Our results indicate that fascin status does not correlate with progression in melanoma. Upregulated fascin expression was detected in melanoma metastases, but was not correlated to patient outcome.
Item Type: | Articles |
---|---|
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Machesky, Professor Laura and Faller, Dr William and Ma, Dr Yafeng and Sansom, Professor Owen |
Authors: | Ma, Y., Faller, W., Sansom, O., Brown, E. R., Doig, T. N., Melton, D. W., and Machesky, L. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | Melanoma Research |
Publisher: | Lippincott, Williams & Wilkins |
ISSN: | 0960-8931 |
ISSN (Online): | 1473-5636 |
University Staff: Request a correction | Enlighten Editors: Update this record