Aprahamian, T. R., Zhong, X., Amir, S., Binder, C. J., Chiang, L.-K., Al-Riyami, L., Gharakhanian, R., Harnett, M. M. , Harnett, W. and Rifkin, I. R. (2015) The immunomodulatory parasitic worm product ES-62 reduces lupus-associated accelerated atherosclerosis in a mouse model. International Journal for Parasitology, 45(4), pp. 203-207. (doi: 10.1016/j.ijpara.2014.12.006) (PMID:25666929) (PMCID:PMC4355381)
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Abstract
ES-62 is an anti-inflammatory phosphorylcholine-containing glycoprotein secreted by the filarial nematode Acanthocheilonema viteae. Accelerated atherosclerosis frequently occurs in systemic lupus erythematosus, resulting in substantial cardiovascular morbidity and mortality. We examined the effects of ES-62 in the gld.apoE−/− mouse model of this condition. Treatment with ES-62 did not substantially modulate renal pathology but caused decreased anti-nuclear autoantibody levels. Moreover, a striking 60% reduction in aortic atherosclerotic lesions was observed, with an associated decrease in macrophages and fibrosis. We believe that these latter findings constitute the first example of a defined parasitic worm product with therapeutic potential in atherosclerosis: ES-62-based drugs may represent a novel approach to control accelerated atherosclerosis in systemic lupus erythematosus.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Harnett, Professor Margaret |
| Authors: | Aprahamian, T. R., Zhong, X., Amir, S., Binder, C. J., Chiang, L.-K., Al-Riyami, L., Gharakhanian, R., Harnett, M. M., Harnett, W., and Rifkin, I. R. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | International Journal for Parasitology |
| Publisher: | Elsevier |
| ISSN: | 0020-7519 |
| ISSN (Online): | 1879-0135 |
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