IL-10-producing regulatory B cells induced by IL-33 (BregIL-33) effectively attenuate mucosal inflammatory responses in the gut

Sattler, S. et al. (2014) IL-10-producing regulatory B cells induced by IL-33 (BregIL-33) effectively attenuate mucosal inflammatory responses in the gut. Journal of Autoimmunity, 50, pp. 107-122. (doi: 10.1016/j.jaut.2014.01.032) (PMID:24491821) (PMCID:PMC4012142)

Abstract

Regulatory B cells (Breg) have attracted increasing attention for their roles in maintaining peripheral tolerance. Interleukin 33 (IL-33) is a recently identified IL-1 family member, which leads a double-life with both pro- and anti-inflammatory properties. We report here that peritoneal injection of IL-33 exacerbated inflammatory bowel disease in IL-10-deficient (IL-10−/−) mice, whereas IL-33-treated IL-10-sufficient (wild type) mice were protected from the disease induction. A phenotypically unconventional subset(s) (CD19+CD25+CD1dhiIgMhiCD5-CD23-Tim-1-) of IL-10 producing Breg-like cells (BregIL-33) was identified responsible for the protection. We demonstrated further that BregIL-33 isolated from these mice could suppress immune effector cell expansion and functions and, upon adoptive transfer, effectively blocked the development of spontaneous colitis in IL-10−/− mice. Our findings indicate an essential protective role, hence therapeutic potential, of BregIL-33 against mucosal inflammatory disorders in the gut.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Liew, Prof Foo and Xu, Dr Damo
• Authors: Sattler, S., Ling, G.-S., Xu, D., Hussaarts, L., Romaine, A., Zhao, H., Fossati-Jimack, L., Malik, T., Cook, H. T., Botto, M., Lau, Y.-L., Smits, H. H., Liew, F. Y., and Huang, F.-P.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Journal of Autoimmunity
• Publisher: Elsevier Ltd.
• ISSN: 0896-8411
• ISSN (Online): 1095-9157
• Copyright Holders: Copyright © 2014 Crown Copyright
• First Published: First published in the Journal of Autoimmunity 50:107-122
• Publisher Policy: Reproduced under a Creative Commons License