Estampador, A. C., Pomeroy, J., Renstrom, F., Nelson, S. M. , Mogren, I., Persson, M., Sattar, N. , Domellof, M. and Franks, P. W. (2014) Infant body composition and adipokine concentrations in relation to maternal gestational weight gain. Diabetes Care, 37(5), pp. 1432-1438. (doi: 10.2337/dc13-2265) (PMID:24623025) (PMCID:PMC3994936)
|
Text
105120.pdf - Published Version Available under License Creative Commons Attribution Non-commercial No Derivatives. 828kB |
Abstract
OBJECTIVE To investigate associations of maternal gestational weight gain and body composition and their impact on offspring body composition and adipocytokine, glucose, and insulin concentrations at age 4 months.
RESEARCH DESIGN AND METHODS This was a prospective study including 31 mother-infant pairs (N = 62). Maternal body composition was assessed using doubly labeled water. Infant body composition was assessed at 4 months using air displacement plethysmography, and venous blood was assayed for glucose, insulin, adiponectin, interleukin-6 (IL-6), and leptin concentrations. RESULTS Rate of gestational weight gain in midpregnancy was significantly associated with infant fat mass (r = 0.41, P = 0.03); rate of gestational weight in late pregnancy was significantly associated with infant fat-free mass (r = 0.37, P = 0.04). Infant birth weight was also strongly correlated with infant fat-free mass at 4 months (r = 0.63, P = 0.0002). Maternal BMI and maternal fat mass were strongly inversely associated with infant IL-6 concentrations (r = −0.60, P = 0.002 and r = −0.52, P = 0.01, respectively). Infant fat-free mass was inversely related to infant adiponectin concentrations (r = −0.48, P = 0.008) and positively correlated with infant blood glucose adjusted for insulin concentrations (r = 0.42, P = 0.04). No significant associations for leptin were observed. CONCLUSIONS Timing of maternal weight gain differentially impacts body composition of the 4-month-old infant, which in turn appears to affect the infant’s glucose and adipokine concentrations.| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Nelson, Professor Scott and Sattar, Professor Naveed |
| Authors: | Estampador, A. C., Pomeroy, J., Renstrom, F., Nelson, S. M., Mogren, I., Persson, M., Sattar, N., Domellof, M., and Franks, P. W. |
| College/School: | College of Medical Veterinary and Life Sciences College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Diabetes Care |
| Publisher: | American Diabetes Association |
| ISSN: | 0149-5992 |
| ISSN (Online): | 1935-5548 |
| Copyright Holders: | Copyright ©2014 by the American Diabetes Association |
| First Published: | First published in Diabetes Care 37(5):1432-1438 |
| Publisher Policy: | Reproduced under a Creative Commons License |
University Staff: Request a correction | Enlighten Editors: Update this record
Funder and Project Information
Funder and Project Information