Structure and diversification of the bovine immunoglobulin repertoire

Aitken, R., Hosseini, A. and MacDuff, R. (1999) Structure and diversification of the bovine immunoglobulin repertoire. Veterinary Immunology and Immunopathology, 72(1-2), pp. 21-29. (doi:10.1016/S0165-2427(99)00113-0) (PMID:10614489)

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Abstract

Our understanding of the basis to immunoglobulin formation in cattle has benefited substantially from the application of molecular biology over the past decade. It is now established that both the lambda light chain and heavy chain repertoires are founded upon the frequent expression of single gene families and subgroups of segments which are of conserved sequence. It is likely that a functional kappa locus exists in the bovine genome but this isotype comprises as few as 5% of bovine light chains. Similarly, alternative but non-expressed VH gene families are present posing intriguing but unresolved questions about the regulation of immunoglobulin synthesis. The heavy chain frequently bears a third complementarity-determining region which is atypically long but the processes which expand this region of the reading frame and its contribution to the interaction with antigen remain matters of speculation. Opportunities exist to map the major immunoglobulin loci and to define the membership and sequence diversity of the gene families which dominate each repertoire. However, it is already evident that cattle cannot generate significant diversity from rearrangement and junctional imprecision alone. Elucidation of the mechanism(s), dynamics and tissue distribution of immunoglobulin diversification in cattle, thus, remain key challenges in this branch of veterinary immunology.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Aitken, Professor Robert
Authors: Aitken, R., Hosseini, A., and MacDuff, R.
College/School:College of Medical Veterinary and Life Sciences > School of Life Sciences
Journal Name:Veterinary Immunology and Immunopathology
Publisher:Elsevier BV
ISSN:0165-2427
ISSN (Online):1873-2534

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