Sbarouni, E., Voudris, V., Georgiadou, P., Hamilos, M., Steg, G., Fox, K. M., Greenlaw, N. and Vardas, P. E. (2015) Heart rate and b-blockade in stable coronary artery disease in Greece. Hellenic Journal of Cardiology, 56, pp. 112-117.
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Publisher's URL: http://www.hellenicjcardiol.com/archive/full_text/2015/2/2015_2_112.pdf
Abstract
Introduction: Heart rate (HR) is a strong prognostic indicator in patients with coronary artery disease (CAD). However, there is only limited evidence on HR and the use of b-blockers in patients with CAD in contemporary clinical practice.
Methods: CLARIFY is an international, prospective, observational, longitudinal registry of outpatients with stable CAD, defined as prior myocardial infarction or revascularization procedure, evidence of coronary stenosis >50%, or chest pain associated with proven myocardial ischemia. A total of 33,283 patients from 45 countries were enrolled between November 2009 and July 2010; of these, 559 patients were enrolled in Greece (age 62.3 ± 10.6 years, 84.44% men). Results: HR measured by pulse was 68.3 ± 10.2 bpm and by electrocardiogram 67.6 ± 10.9, with an excellent correlation (r=0.91, p<0.001). Overall, 42.8% had HR≥70 bpm. B-blockers were prescribed in 74.2% of patients. Resting HR by pulse on b-blocker was 67.8 bpm and without b-blocker 69.6 bpm (p=0.069). HR≥70 bpm was independently associated with a lack of physical activity, higher systolic blood pressure, and a higher prevalence of asthma or chronic obstructive pulmonary disease and carotid artery disease. Conclusion: Despite the use of HR lowering agents, the percentage of patients with HR≥70 bpm was high. It is likely that we can further improve HR control in Greek patients with stable CAD by both increasing the prescription of b-blockers and up-titrating their dose, as well as by using and up-titrating other available HR lowering agents.| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Greenlaw, Miss Nicola |
| Authors: | Sbarouni, E., Voudris, V., Georgiadou, P., Hamilos, M., Steg, G., Fox, K. M., Greenlaw, N., and Vardas, P. E. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre |
| Journal Name: | Hellenic Journal of Cardiology |
| Publisher: | Hellenic Cardiological Society |
| ISSN: | 1109-9666 |
| ISSN (Online): | 2241-5955 |
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