Kalafatovic, D., Nobis, M., Javid, N., Frederix, P. W.J.M., Anderson, K. I., Saunders, B. R. and Ulijn, R. V. (2015) MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin. Biomaterials Science, 3(2), pp. 246-249. (doi: 10.1039/c4bm00297k)
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Abstract
Phenylacetyl-peptide amphiphiles were designed, which upon cleavage by a disease-associated enzyme reconfigure from micellar aggregates to fibres. Upon this morphological change, a doxorubicin payload could be retained in the fibres formed, which makes them valuable carriers for localised formation of nanofibre depots for slow release of hydrophobic anticancer drugs.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Anderson, Professor Kurt and Nobis, Mr Max |
| Authors: | Kalafatovic, D., Nobis, M., Javid, N., Frederix, P. W.J.M., Anderson, K. I., Saunders, B. R., and Ulijn, R. V. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Biomaterials Science |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 2047-4830 |
| ISSN (Online): | 2047-4830 |
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