De las Heras, M., Barsky, S.H., Hasleton, P., Wagner, M., Larson, E., Egan, J., Ortin, A., Gimenez-Mas, J.A., Palmarini, M. and Sharp, J.M. (2000) Evidence for a protein related immunologically to the jaagsiekte sheep retrovirus in some human lung tumours. European Respiratory Journal, 16(2), pp. 330-332. (doi: 10.1034/j.1399-3003.2000.16b23.x)
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Abstract
Human bronchioloalveolar carcinoma (BAC) is a lung cancer, morphologically similar to an endemic contagious lung neoplasm of sheep called sheep pulmonary adenomatosis (SPA) or jaagsiekte. SPA is caused by an exogenous type B/D retrovirus (jaagsiekte sheep retrovirus (JSRV)), which prompted the present study to obtain evidence of a retrovirus in BAC. A panel of 249 human lung tumours, 21 nontumour lung lesions, four normal lung tissues, 23 adenocarcinomas from other organs and a cell line expressing a human endogenous retrovirus protein was examined immunohistochemically using a rabbit antiserum directed against the JSRV capsid protein. Specific staining was detected only in the cytoplasm of recognizably neoplastic cells in the pulmonary alveoli of 39 of 129 (30%) BACs, 17 of 65 (26%) lung adenocarcinomas and two of seven large cell carcinomas. The remaining samples were negative. These results support the hypothesis that some human pulmonary tumours may be associated with a jaagsiekte sheep retrovirus-related retrovirus, warranting further studies.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Palmarini, Professor Massimo |
| Authors: | De las Heras, M., Barsky, S.H., Hasleton, P., Wagner, M., Larson, E., Egan, J., Ortin, A., Gimenez-Mas, J.A., Palmarini, M., and Sharp, J.M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
| Journal Name: | European Respiratory Journal |
| Publisher: | European Respiratory Society |
| ISSN: | 0903-1936 |
| ISSN (Online): | 1399-3003 |
| Related URLs: |
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