Waugh, E. M., Gallagher, A., McAulay, K., Henriques, J., Alves, M., Bell, A. J., Morris, J. S. and Jarrett, R. F. (2015) Gammaherpesviruses and canine lymphoma: no evidence for direct involvement in commonly occurring lymphomas. Journal of General Virology, 96, pp. 1863-1872. (doi: 10.1099/vir.0.000106) (PMID:25722346) (PMCID:PMC4635455)
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Abstract
Lymphoma is the most common haematopoietic malignancy in dogs but little is known about the aetiology of this heterogeneous group of cancers. In humans, the Epstein-Barr virus (EBV) is associated with several lymphoma subtypes. Recently, it has been suggested that EBV or an EBV-like virus is circulating in dogs. We therefore investigated whether EBV, or a novel herpesvirus, is associated with canine lymphoma using both serological and molecular techniques. In an assay designed to detect antibodies to EBV viral capsid antigens, 41% of dogs were positive. Dogs with cancers, including lymphoma, were more frequently positive than controls, but no particular association with B-cell lymphoma was noted. EBV-specific RNA and DNA sequences were not detected in lymphoma tissue by in situ hybridisation or PCR and herpesvirus genomes were not detected using multiple degenerate PCR assays with the ability to detect novel herpesviruses. We therefore found no evidence that herpesviruses are directly involved in common types of canine lymphoma although cannot exclude the presence of an EBV-like virus in the canine population.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Jarrett, Professor Ruth and Morris, Professor Joanna and Gallagher, Dr Alice and Waugh, Ms Elspeth and McAulay, Dr Karen |
Authors: | Waugh, E. M., Gallagher, A., McAulay, K., Henriques, J., Alves, M., Bell, A. J., Morris, J. S., and Jarrett, R. F. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
Journal Name: | Journal of General Virology |
Publisher: | Society for General Microbiology |
ISSN: | 0022-1317 |
ISSN (Online): | 1465-2099 |
Copyright Holders: | Copyright © 2015 The Authors |
First Published: | First published in Journal of General Virology |
Publisher Policy: | Reproduced under a Creative Commons License |
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