Adrenomedullin selectively inhibits angiotensin II-induced aldosterone secretion in humans

Petrie, M. C. , Hillier, C., Morton, J. and McMurray, J. J.V. (2000) Adrenomedullin selectively inhibits angiotensin II-induced aldosterone secretion in humans. Journal of Hypertension, 18(1), pp. 61-64. (doi:10.1097/00004872-200018010-00009) (PMID:10678544)

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Objective: Adrenomedullin inhibits angiotensin II stimulated aldosterone production in vitro and in vivo in experimental animals. The aim of this study was to investigate the effect of adrenomedullin on angiotensin II and adrenocorticotrophic hormone-stimulated aldosterone production in vivo in healthy humans.<p></p>   Design and Methods: Seven volunteers were studied in a quiet, temperature-controlled laboratory. After 35 min of rest, an infusion of placebo or adrenomedullin (3 pmol/kg per min) was given over 60 min; 15 min after starting this first infusion, a second infusion of angiotensin II (0.96 fmol/kg per min) or adrenocorticotrophic hormone (0.1 mIU/kg per min) was co-infused and continued for 45 min. <p></p>   Results: Adrenomedullin significantly inhibited angiotensin II stimulated aldosterone production: the increment in aldosterone on the placebo day was 691 pmol/l compared with 552 pmol/l on the adrenomedullin day (P < 0.004). Adrenomedullin did not inhibit adrenocorticotrophic hormone-stimulated aldosterone or cortisol release.<p></p>   Conclusion: Adrenomedullin selectively inhibits angiotensin II-stimulated aldosterone production.<p></p>

Item Type:Articles
Glasgow Author(s) Enlighten ID:Morton, Dr James and Petrie, Professor Mark and McMurray, Professor John
Authors: Petrie, M. C., Hillier, C., Morton, J., and McMurray, J. J.V.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Journal of Hypertension
Publisher:Lippincott Williams & Wilkins
ISSN (Online):1473-5598

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