Atrial natriuretic factor attenuates prostaglandin E2-stimulated plasma renin activity in humans

McMurray, J. , McFarlane, L., Coutie, W., Balfour, D. and Struthers, A. (1989) Atrial natriuretic factor attenuates prostaglandin E2-stimulated plasma renin activity in humans. Journal of Cardiovascular Pharmacology, 14(2), pp. 326-330. (doi: 10.1097/00005344-198908000-00021) (PMID:2476609)

Abstract

The effect of atrial natriuretic factor (ANF) 99-126 3 or 10 pmol/kg/min on increase in plasma renin activity (PRA) stimulated by a 30-min infusion of prostaglandin E2 (PGE2) 80 ng/kg/min was studied in healthy salt-replete male volunteers. PGE2 increased PRA to -230% of basal levels (p < 0.001). Concomitant infusion of ANF 3 pmol/kg/min significantly attenuated this rise in PRA to -130% of baseline values (p = 0.02, n = 10). A quantitatively similar effect was observed with ANF 10 pmol/kg/min (n = 5). We suggest, in light of previous findings, that this inhibitory effect of ANF probably represents a nonspecific action rather than a specific effect of ANF on PGE2-mediated increases in PRA.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: McMurray, Professor John
• Authors: McMurray, J., McFarlane, L., Coutie, W., Balfour, D., and Struthers, A.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Journal of Cardiovascular Pharmacology
• Publisher: Lippincott Williams & Wilkins
• ISSN: 0160-2446
• ISSN (Online): 1533-4023