Health related quality of life in I-PRESERVE trial

Carson, P. et al. (2008) Health related quality of life in I-PRESERVE trial. Journal of Cardiac Failure, 14(6), S73. (doi: 10.1016/j.cardfail.2008.06.200)

Abstract

Purpose: Little is known about health-related quality of life (QHRQL) in patients with HF and preserved EF (HF-PEF). We studied the impact of HF-PEF on HRQL (and the determinants of HRQL in patients with HF-PEF) in the Irbesartan in Heart Failure with Preserved Systolic Function trial.<p></p> Methods: At baseline, 3,622 patients with an EF ≥ 45% from 25 countries completed the extensively studied and validated Minnesota Living with Heart Failure questionnaire (MLwHF), a 21 item disease-specific instrument. A summary score of 0–105 is possible, with a higher score reflecting worse HRQL. In order to examine relationships between pathophysiology, symptoms/signs and HRQL, NYHA class (see table), peripheral oedema (see table), EF (quartiles) and plasma concentration of NT proBNP (quartiles) were divided into 4 categories.<p></p> Results: Mean age was 72 (range 53–95) years and 61% were female. Mean MLwHF score was 42.4 (SD 20.7). There was no relationship between EF or NT proBNP and HRQL whereas NYHA class and oedema were strongly correlated with HROL.<p></p>

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: McMurray, Professor John
• Authors: Carson, P., McMurray, J., Komajda, M., Zile, M., Ptaszynska, A., Jackson, J., McKelvie, R., Rector, T., Grinspan, J., Staiger, C., and Massie, B.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Journal of Cardiac Failure
• Publisher: Elsevier Inc.
• ISSN: 1071-9164
• ISSN (Online): 1532-8414