Sans Sangorrin, V., Porwol, L., Dragone, V. and Cronin, L. (2015) A self optimizing synthetic organic reactor system using real-time in-line NMR spectroscopy. Chemical Science, 6(2), pp. 1258-1264. (doi: 10.1039/C4SC03075C)
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Abstract
A configurable platform for synthetic chemistry incorporating an in-line benchtop NMR that is capable of monitoring and controlling organic reactions in real-time is presented. The platform is controlled via a modular LabView software control system for the hardware, NMR, data analysis and feedback optimization. Using this platform we report the real-time advanced structural characterization of reaction mixtures, including 19F, 13C, DEPT, 2D NMR spectroscopy (COSY, HSQC and 19F-COSY) for the first time. Finally, the potential of this technique is demonstrated through the optimization of a catalytic organic reaction in real-time, showing its applicability to self-optimizing systems using criteria such as stereoselectivity, multi-nuclear measurements or 2D correlations.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Cronin, Professor Lee and Sans Sangorrin, Dr Victor |
Authors: | Sans Sangorrin, V., Porwol, L., Dragone, V., and Cronin, L. |
College/School: | College of Science and Engineering > School of Chemistry |
Journal Name: | Chemical Science |
Publisher: | R S C Publications |
ISSN: | 2041-6520 |
ISSN (Online): | 2041-6539 |
Copyright Holders: | Copyright © 2015 The Royal Society of Chemistry |
First Published: | First published in Chemical Science 6(2):1258-1264 |
Publisher Policy: | Reproduced under a Creative Commons License |
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