Khan, M. J., Humayun, K. N., Donaldson, M., Ahmed, S. F. and Shaikh, M. G. (2015) Longitudinal changes in body mass index in children with craniopharyngioma. Hormone Research in Paediatrics, 82(6), pp. 372-379. (doi: 10.1159/000368798) (PMID:25359623)
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Abstract
Objective: We investigated the relationship of body mass index at presentation and pituitary status with long-term changes in BMI over a period of 5 years. Study Design: Craniopharyngioma patients (n = 25) attending a tertiary pediatric endocrine center were divided into three groups based on their BMI at presentation [BMI ≥2 standard deviation scores (SDS), 0-1.99 SDS, and <0 SDS) and then analyzed for trends of BMI over a period of up to 5 years. Results: Median (interquartile range) BMI SDS and hypopituitarism at presentation versus at the 5-year follow-up were as follows: BMI SDS ≥2 group (n = 10): 3.55 (0.68), 6/10 versus 3.76 (1.13), 8/10; BMI SDS 0-1.99 group (n = 11): 1.68 (1.05), 3/11 versus 1.64 (2.04), 7/11, and BMI SDS <0 group (n = 4): -0.23 (0.93), 2/4 versus 0.61, 4/4. At the 5-year follow-up, 10/10, 7/11, and 1/4 subjects when divided in groups according to BMI at presentation were obese. Conclusions: Our data indicate that obesity at presentation, rather than panhypopituitarism either at or after presentation, predicts obesity 5 years after diagnosis. However, obesity at presentation is not always associated with the subsequent development of panhypopituitarism. Pediatric craniopharyngioma subjects who have BMI SDS ≥2 at presentation require early and aggressive intervention to help prevent the complications of obesity.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Shaikh, Dr Mohammed Guftar and Khan, Mr Muhammad and Ahmed, Professor Syed Faisal and Donaldson, Dr Malcolm |
Authors: | Khan, M. J., Humayun, K. N., Donaldson, M., Ahmed, S. F., and Shaikh, M. G. |
College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
Journal Name: | Hormone Research in Paediatrics |
Publisher: | S. Karger AG |
ISSN: | 1663-2818 |
ISSN (Online): | 1663-2826 |
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