Toscano, M.D., Stewart, K.A., Coggins, J.R., Lapthorn, A.J. and Abell, C. (2005) Rational design of new bifunctional inhibitors of type II dehydroquinase. Organic and Biomolecular Chemistry, 3, pp. 3102-3104. (doi: 10.1039/B507156A)
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Abstract
Selective inhibitors of type II dehydroquinase were rationally designed to explore a second binding-pocket in the active-site. The molecular modelling, synthesis, inhibition studies and crystal structure determination are described.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Lapthorn, Dr Adrian and Coggins, Professor John |
| Authors: | Toscano, M.D., Stewart, K.A., Coggins, J.R., Lapthorn, A.J., and Abell, C. |
| Subjects: | Q Science > QH Natural history > QH345 Biochemistry |
| College/School: | College of Science and Engineering > School of Chemistry College of Medical Veterinary and Life Sciences |
| Journal Name: | Organic and Biomolecular Chemistry |
| ISSN: | 1477-0520 |
| Published Online: | 01 August 2005 |
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