Saito, H., Morikawa, H., Howie, K., Crawford, L., Baatjes, A. J., Denburg, E., Cyr, M. M. and Denburg, J. A. (2004) Effects of a cysteinyl leukotriene receptor antagonist on eosinophil recruitment in experimental allergic rhinitis. Immunology, 113(2), pp. 246-252. (doi: 10.1111/j.1365-2567.2004.01944.x)
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Publisher's URL: http://dx.doi.org/10.1111/j.1365-2567.2004.01944.x
Abstract
The cysteinyl leukotrienes (cysLTs) are potent lipid mediators in allergic disease, acting through a receptor (cysLT1-R) which can be targeted in rhinitis and asthma. We investigated the effects of cysLT1-R antagonism in experimental allergic rhinitis, focusing on bone marrow eosinophil progenitor responses. BALB/c mice were sensitized, then given daily intranasal ovalbumin for 2 weeks, with montelukast sodium (5 mg/kg or 2·5 mg/kg) or placebo by gavage. Bone marrow eosinophil/basophil colonies were enumerated, and colony cells were morphologically assessed as indices of eosinophil differentiation and maturation. Montelukast treatment resulted in a significant decrease of eosinophils in the nasal mucosa, and in either bone marrow interleukin (IL)-5-, but not IL-3-, or granulocyte-macrophage colony-stimulating factor-responsive eosinophil/basophil colony-forming units, and IL-5-stimulated eosinophil maturation. These results indicate that cysLT1-R antagonism in vivo limits both IL-5-responsive eosinophilopoiesis, acting at several stages of eosinophil differentiation and maturation. The anti-allergic effects of cysLT1-R antagonists are consistent with the concept that cysLTs and IL-5 act together in the recruitment of eosinophils and eosinophil progenitors from the marrow during upper airway allergic inflammation.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Stewart, Ms Lynn |
| Authors: | Saito, H., Morikawa, H., Howie, K., Crawford, L., Baatjes, A. J., Denburg, E., Cyr, M. M., and Denburg, J. A. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Immunology |
| Publisher: | Blackwell Publishing Ltd. |
| ISSN: | 0019-2805 |
| ISSN (Online): | 1365-2567 |
| Related URLs: |
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