Abnormal IL-2 receptor levels in non-pregnant women with a history of recurrent miscarriage

Wilson, R., Moore, J., Jenkins, C., Miller, H., Maclean, M.A., McInnes, I.B. and Walker, J.J. (2003) Abnormal IL-2 receptor levels in non-pregnant women with a history of recurrent miscarriage. Human Reproduction, 18(7), pp. 1529-1530. (doi: 10.1093/humrep/deg287)

Abstract

BACKGROUND: Immunological abnormalities have been found in pregnant women with a history of recurrent miscarriage. This study compared interleukin-2 receptor (IL-2R) levels in non-pregnant women with a history of recurrent miscarriage with those found in serum from a non-pregnant group with no such history. <br/><br/> METHODS: Group 1 comprised 49 non-pregnant women with a history of recurrent miscarriage (at least three consecutive miscarriages). Group 2 comprised 22 non-pregnant women with no history of miscarriage. Serum IL-2R levels were measured in all patients. <br/><br/>RESULTS: The results obtained showed that although all women were not pregnant at the time of sampling, IL-2R levels were significantly higher in women in Group 1 compared with those in Group 2 (1589 ± 1289 versus 1082 ± 823 pg/ml; P < 0.05). Follow-up data were available for 21 women from Group 1. The next pregnancy ended successfully for 14 of these women, while seven miscarried again. The IL-2R levels obtained pre-pregnancy were not significantly different between the two groups (1480 ± 910 versus 1356 ± 716 pg/ml). <br/><br/>CONCLUSION: This study has shown that non-pregnant women with a history of recurrent miscarriage have raised IL-2R levels. These increased pre-pregnancy IL-2R levels did not necessarily predict miscarriage for the next pregnancy.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: McInnes, Professor Iain and Maclean, Dr Marjory
• Authors: Wilson, R., Moore, J., Jenkins, C., Miller, H., Maclean, M.A., McInnes, I.B., and Walker, J.J.
• Subjects: Q Science > QR Microbiology > QR180 Immunology; R Medicine > RG Gynecology and obstetrics; Q Science > QP Physiology
• College/School: College of Medical Veterinary and Life Sciences; College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Human Reproduction
• ISSN: 0268-1161