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PlasmaN-acetyl-glucosaminidase in advanced gastro-intestinal adenocarcinoma correlates with age, stage and outcome

Hartmann, D., von Figura, G., Song, Z., Harden, S., Scott, L. C., Evans, T. J. , Rudolph, K. L., Bilsland, A. E. and Keith, W. N. (2015) PlasmaN-acetyl-glucosaminidase in advanced gastro-intestinal adenocarcinoma correlates with age, stage and outcome. Future Oncology, 11(2), pp. 193-203. (doi: 10.2217/fon.14.166)

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Publisher's URL: http://dx.doi.org/10.2217/fon.14.166

Abstract

Background:N-acetyl-glucosaminidase (NAG) is a potential marker of genotoxicity. We retrospectively analyzed plasma NAG and clinico-pathologic features in advanced gastrointestinal adenocarcinoma patients. Methods: Plasma from 118 patients and 51 healthy volunteers was analyzed for associations between NAG levels and age, disease presence, stage, treatment responses and survival. Results:Pretreatment NAG correlated with age but was independently increased in metastatic versus locally advanced disease, particularly in gastric/esophageal patients. NAG was also associated with reduced overall survival. In subgroup analysis, increased NAG activity between day 1 and 2 of chemotherapy cycle 1 correlated with treatment response.Conclusion:We demonstrated that NAG correlates with gastrointestinal cancer outcomes. Further studies are required to determine if plasma markers of genotoxicity can be useful for disease monitoring.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Harden, Ms Sharon and Scott, Dr Lucy and Bilsland, Dr Alan and Evans, Professor Jeff and Keith, Professor Nicol
Authors: Hartmann, D., von Figura, G., Song, Z., Harden, S., Scott, L. C., Evans, T. J., Rudolph, K. L., Bilsland, A. E., and Keith, W. N.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Future Oncology
Publisher:Future Medicine Ltd.
ISSN:1479-6694
ISSN (Online):1744-8301
Copyright Holders:Copyright © 2015 The Authors
First Published:First published in Future Oncology 11(2):193-203
Publisher Policy:Reproduced under a Creative Commons License
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