Maffia, P. , Brewer, J. M. , Gracie, J. A., Ianaro, A., Leung, B. P., Mitchell, P. J., Smith, K. M., McInnes, I. B. and Garside, P. (2004) Inducing experimental arthritis and breaking self-tolerance to joint-specific antigens with trackable, ovalbumin-specific T cells. Journal of Immunology, 173(1), pp. 151-156. (doi: 10.4049/jimmunol.173.1.151) (PMID:15210769)
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Publisher's URL: http://www.jimmunol.org/cgi/content/abstract/173/1/151
Abstract
The importance of T cell Ag specificity and Th1 vs Th2 phenotype in synovial inflammation remains controversial. Using OVA-specific TCR transgenic T cells from DO11.10 mice, we demonstrate that mice receiving Th1, but not Th2, cells display a transient arthritis following immunization that is characterized by synovial hyperplasia, cellular infiltration, and cartilage erosion. OVA-specific T cells also accumulated in inflamed joints, suggesting that they could exert their inflammatory effect locally in the joint or in the draining lymph node. Importantly, this pathology was accompanied by a breakdown in self-tolerance, as evidenced by the induction of collagen-specific T and B cell responses. This model directly demonstrates a pivotal role for Th1 cells of an irrelevant specificity in the development of inflammatory arthritis. Furthermore, the ability to track these cells in vivo will make feasible studies revealing the dynamic role of T cells in arthritis.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | McInnes, Professor Iain and Maffia, Professor Pasquale and Leung, Dr Bernard and Gracie, Professor Alastair and Garside, Professor Paul and Smith, Ms Karen and Brewer, Professor James |
| Authors: | Maffia, P., Brewer, J. M., Gracie, J. A., Ianaro, A., Leung, B. P., Mitchell, P. J., Smith, K. M., McInnes, I. B., and Garside, P. |
| Subjects: | Q Science > QR Microbiology > QR180 Immunology R Medicine > RC Internal medicine |
| College/School: | College of Medical Veterinary and Life Sciences College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School |
| Journal Name: | Journal of Immunology |
| Journal Abbr.: | J. Immunol. |
| Publisher: | American Association of Immunologists |
| ISSN: | 0022-1767 |
| ISSN (Online): | 1550-6606 |
| Published Online: | 21 June 2004 |
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