Neural oscillations as a translational tool in schizophrenia research: rationale, paradigms and challenges

Phillips, K. G. and Uhlhaas, P. J. (2015) Neural oscillations as a translational tool in schizophrenia research: rationale, paradigms and challenges. Journal of Psychopharmacology, 29(2), pp. 155-168. (doi:10.1177/0269881114562093)

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Abstract

Neural oscillations have received recently a great deal of interest in schizophrenia research because of the possibility to integrate findings from non-invasive electro/magnetoencephalographical recordings with pre-clinical research, which could potentially lead to the identification of pathophysiological mechanisms and novel treatment targets. In the current paper, we review the potential as well as the challenges of this approach by summarizing findings on alterations in rhythmic activity from both animal models and human data which have implicated dysfunctional neural oscillations in the explanation of cognitive deficits and certain clinical symptoms of schizophrenia. Specifically, we will focus on findings that have examined neural oscillations during 1) perceptual processing, 2) working memory and executive processes and 3) spontaneous activity. The importance of the development of paradigms suitable for human and animal models is discussed as well as the search for mechanistic explanation for oscillatory dysfunctions.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Uhlhaas, Professor Peter
Authors: Phillips, K. G., and Uhlhaas, P. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Journal of Psychopharmacology
Publisher:SAGE Publications
ISSN:0269-8811
ISSN (Online):1461-7285

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