Oscillations and neuronal dynamics in schizophrenia: the search for basic symptoms and translational opportunities

Uhlhaas, P. J. and Singer, W. (2015) Oscillations and neuronal dynamics in schizophrenia: the search for basic symptoms and translational opportunities. Biological Psychiatry, 77(12), pp. 1001-1009. (doi:10.1016/j.biopsych.2014.11.019)

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Abstract

A considerable body of work over the last 10 years combining non-invasive electrophysiology (EEG/MEG) in patient populations with pre-clinical research has contributed to the conceptualization of schizophrenia as a disorder associated with of aberrant neural dynamics and disturbances in Excitation/Inhibition-(E/I) balance. This complements previous research that has largely focussed on the identification of abnormalities in circumscribed brain regions and on disturbances of dopaminergic mechanisms as a cause of positive symptoms and executive deficits. In the current review, we provide an update on studies focussing on aberrant neural dynamics. First, we discuss the role of rhythmic activity in neural dynamics and in the coordination of distributed neuronal activity into organized neural states. This is followed by an overview on the current evidence for impaired neural oscillations and synchrony in schizophrenia and associated abnormalities in GABAergic and glutamatergic neurotransmission. Finally, we will discuss the distinction between ‘fundamental’ symptoms which are reflected in cognitive deficits and psychotic, accessory symptoms, the latter likely constituting a compensatory response for aberrant neuronal dynamics.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Uhlhaas, Professor Peter
Authors: Uhlhaas, P. J., and Singer, W.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Biological Psychiatry
Publisher:Elsevier Inc.
ISSN:0006-3223
ISSN (Online):1873-2402

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