Tarafdar, A. and Michie, A. M. (2014) Protein kinase C in cellular transformation: a valid target for therapy? Biochemical Society Transactions, 42(6), pp. 1556-1562. (doi: 10.1042/BST20140255) (PMID:25399570)
|
Text
101077.pdf - Published Version Available under License Creative Commons Attribution. 315kB |
Abstract
The protein kinase C (PKC) family of serine/threonine protein kinases share structural homology, while exhibiting substantial functional diversity. PKC isoforms are ubiquitously expressed in tissues which makes it difficult to define roles for individual isoforms, with complexity compounded by the finding that PKC isoforms can co-operate with or antagonize other PKC family members. A number of studies suggest the involvement of PKC family members in regulating leukaemic cell survival and proliferation. Chronic lymphocytic leukaemia (CLL), the most common leukaemia in the Western world, exhibits dysregulated expression of PKC isoforms, with recent reports indicating that PKCβ and δ play a critical role in B-cell development, due to their ability to link the B-cell receptor (BCR) with downstream signalling pathways. Given the prognostic significance of the BCR in CLL, inhibition of these BCR/PKC-mediated signalling pathways is of therapeutic relevance. The present review discusses the emerging role of PKC isoforms in the pathophysiology of CLL and assesses approaches that have been undertaken to modulate PKC activity.
| Item Type: | Articles |
|---|---|
| Additional Information: | The final version of record is available at http://www.biochemsoctrans.org/content/42/6/1556 |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Michie, Professor Alison and Tarafdar, Ms Anuradha |
| Authors: | Tarafdar, A., and Michie, A. M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Biochemical Society Transactions |
| Publisher: | Portland Press |
| ISSN: | 0300-5127 |
| ISSN (Online): | 1470-8752 |
| Copyright Holders: | Copyright © 2014 Biochemical Society |
| First Published: | First published in Biochemical Society Transactions 42(6):1556-1562 |
| Publisher Policy: | Reproduced under a Creative Commons License |
University Staff: Request a correction | Enlighten Editors: Update this record
Funder and Project Information
Funder and Project Information