The role of Cytochrome P450 17-alpha-Hydroxylase/ 17,20-Lyase (CYP17) in the stress coping ability in a divergently selected Merino sheep population

Van der Walt, D., Cloete, S.W.P., Storbeck, K. and Swart, P. (2009) The role of Cytochrome P450 17-alpha-Hydroxylase/ 17,20-Lyase (CYP17) in the stress coping ability in a divergently selected Merino sheep population. In: 18th Association for the Advancement of Animal Breeding and Genetics Conference, Barossa Valley, South Australia, 28 Sep - 1 Oct 2009, pp. 100-103.

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Abstract

South African Merino sheep were selected divergently from the same base population for their ability to rear multiples. Two distinct populations were formed over a period of more than 20 years of selection. Reproduction (and therefore presumably fitness) in the line selected in the upward direction (H-line) was substantially improved compared to the line selected in the downward direction (L-line). In the present study, it was demonstrated that the H-line was more stresstolerant than the L-line in terms of their glucose and cortisol response when challenged with insulin. Sheep from the breeding program were genotyped according to one of two cytochrome P450 17α-hydroxylase/17-20 lyase (CYP17) alleles, as these genotypes were previously linked to the ability of Angora goats to cope with external stressors. However, no association was found between CYP17 genotype and selection line. The difference in insulin induced stress response between the H- and the L-line can therefore not be attributed to CYP17 genotype.

Item Type:Conference Proceedings
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hough, Dr Denise
Authors: Van der Walt, D., Cloete, S.W.P., Storbeck, K., and Swart, P.
Subjects:Q Science > Q Science (General)
S Agriculture > S Agriculture (General)
College/School:College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
Research Group:Stellenbosch University
Copyright Holders:Copyright © 2009 The Authors
Publisher Policy:Reproduced with the permission of the authors

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