Callard, R. E., Stark, J. and Yates, A. J. (2003) Fratricide: a mechanism for T memory-cell homeostasis. Trends in Immunology, 24(7), pp. 370-375. (doi: 10.1016/S1471-4906(03)00164-9)
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Publisher's URL: http://dx.doi.org/10.1016/S1471-4906(03)00164-9
Abstract
mmunological memory depends on a self-renewing pool of antigen-specific T memory (Tm) cells but the homeostatic mechanisms that maintain the size and diversity of the pool are largely unknown. Competition for space or growth factors has been suggested as a mechanism but how these factors themselves are regulated is unclear. We suggest that Tm-cell fratricide by Fas-mediated apoptosis results in a density-dependent death rate that controls the size of the pool without requiring competition for resources or an external quorum-sensing mechanism. A mathematical model based on this concept predicts the known behaviour of the Tm pool, including observed differences in heterogeneity of the CD4 and CD8 compartments and might provide a paradigm for homeostasis of other haematopoietic-cell populations.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Yates, Professor Andrew |
| Authors: | Callard, R. E., Stark, J., and Yates, A. J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Trends in Immunology |
| Publisher: | Elsevier Science Ltd. |
| ISSN: | 1471-4906 |
| ISSN (Online): | 1471-4981 |
| Related URLs: |
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