Fratricide: a mechanism for T memory-cell homeostasis

Callard, R. E., Stark, J. and Yates, A. J. (2003) Fratricide: a mechanism for T memory-cell homeostasis. Trends in Immunology, 24(7), pp. 370-375. (doi:10.1016/S1471-4906(03)00164-9)

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mmunological memory depends on a self-renewing pool of antigen-specific T memory (Tm) cells but the homeostatic mechanisms that maintain the size and diversity of the pool are largely unknown. Competition for space or growth factors has been suggested as a mechanism but how these factors themselves are regulated is unclear. We suggest that Tm-cell fratricide by Fas-mediated apoptosis results in a density-dependent death rate that controls the size of the pool without requiring competition for resources or an external quorum-sensing mechanism. A mathematical model based on this concept predicts the known behaviour of the Tm pool, including observed differences in heterogeneity of the CD4 and CD8 compartments and might provide a paradigm for homeostasis of other haematopoietic-cell populations.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Yates, Professor Andrew
Authors: Callard, R. E., Stark, J., and Yates, A. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Trends in Immunology
Publisher:Elsevier Science Ltd.
ISSN (Online):1471-4981
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