Yates, A. J. (2014) Theories and quantification of thymic selection. Frontiers in Immunology, 5, p. 13. (doi: 10.3389/fimmu.2014.13)
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Publisher's URL: http://dx.doi.org/10.3389/fimmu.2014.00013
Abstract
The peripheral T cell repertoire is sculpted from prototypic T cells in the thymus bearing randomly generated T cell receptors (TCR) and by a series of developmental and selection steps that remove cells that are unresponsive or overly reactive to self-peptide–MHC complexes. The challenge of understanding how the kinetics of T cell development and the statistics of the selection processes combine to provide a diverse but self-tolerant T cell repertoire has invited quantitative modeling approaches, which are reviewed here.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Yates, Professor Andrew |
| Authors: | Yates, A. J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Frontiers in Immunology |
| Publisher: | Frontiers |
| ISSN: | 1664-3224 |
| Copyright Holders: | Copyright © 2014 The Author |
| First Published: | First published in Frontiers in Immunology 5:00013 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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