Price, A. H., Welsh, P. , Weir, C. J., Feinkohl, I., Robertson, C. M., Morling, J. R., McLachlan, S., Strachan, M. W. J., Sattar, N. and Price, J. F. (2014) N-terminal pro-brain natriuretic peptide and risk of cardiovascular events in older patients with type 2 diabetes: the Edinburgh Type 2 Diabetes Study. Diabetologia, 57(12), pp. 2505-2512. (doi: 10.1007/s00125-014-3375-9)
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Publisher's URL: http://dx.doi.org/10.1007/s00125-014-3375-9
Abstract
<i>Aims/hypothesis</i> The aim of this study was to investigate the association of N-terminal pro-brain natriuretic peptide (NT-proBNP) with traditional cardiovascular risk factors and incident cardiovascular events in older people with type 2 diabetes.<p></p> <i>Methods</i> In the prospective phase of the Edinburgh Type 2 Diabetes Study, 1066 men and women aged 60 to 75 years with type 2 diabetes mellitus were followed for 4 years; 112 participants had an incident cardiovascular event. At baseline, cardiovascular risk factors, pre-existing cardiovascular disease and levels of NT-proBNP were evaluated.<p></p> <i>Results</i> Raised plasma NT-proBNP levels were associated with these classical cardiovascular risk factors: increased duration of diabetes, use of insulin, raised BMI, reduced HDL-cholesterol, reduced renal function and use of lipid-lowering and anti-hypertensive medication (all p < 0.05). In the prospective analysis, NT-proBNP was strongly associated with subsequent risk of all cardiovascular disease events (HR per one SD increase in NT-proBNP 1.39; 95% CI 1.10, 1.75), independent of cardiovascular risk factors traditionally used to predict vascular events. NT-proBNP was also independently associated with incident coronary artery disease events (1.48, 95% CI 1.10, 1.98). The addition of NT-proBNP to multivariate models improved the C-index by 0.019 for the ‘hard’ cardiac endpoint (fatal and non-fatal myocardial infarction).<p></p> <i>Conclusions/interpretation</i> In older people with type 2 diabetes, NT-proBNP is associated with the development of coronary and cerebrovascular events, independent of a wide range of other vascular and metabolic risk factors, and may prove a useful addition to current vascular risk scores in diabetes populations.<p></p>
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Weir, Christopher and Welsh, Professor Paul and Sattar, Professor Naveed |
| Authors: | Price, A. H., Welsh, P., Weir, C. J., Feinkohl, I., Robertson, C. M., Morling, J. R., McLachlan, S., Strachan, M. W. J., Sattar, N., and Price, J. F. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Diabetologia |
| Publisher: | Springer-Verlag |
| ISSN: | 0012-186X |
| ISSN (Online): | 1432-0428 |
| Related URLs: |
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