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De Heuvel, E. et al. (2019) Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors. Bioorganic and Medicinal Chemistry, 27(18), pp. 3998-4012. (doi: 10.1016/j.bmc.2019.06.027) (PMID:31327675)

Botros, S. S. et al. (2019) Screening of a PDE-focused library identifies imidazoles with in vitro and in vivo antischistosomal activity. International Journal for Parasitology: Drugs and Drug Resistance, 9, pp. 35-43. (doi: 10.1016/j.ijpddr.2019.01.001)

Siciliano de Araújo, J., Garcia-Rubia, A., Sebastian-Perez, V., Kalejaiye, T. D., Bernardino da Silva, P., Fonseca-Berzal, C. R., Maes, L., De Koning, H. P. , de Nazaré Correia Soeiroa, M. and Gil, C. (2019) Imidazole derivatives as promising agents for the treatment of Chagas disease. Antimicrobial Agents and Chemotherapy, 63(4), e02156-18. (doi: 10.1128/AAC.02156-18)

Sebastián-Pérez, V., Hendrickx, S., Munday, J. C. , Kalejaiye, T., Martínez, A., Campillo, N. E., de Koning, H. , Caljon, G., Maes, L. and Gil, C. (2018) Cyclic nucleotide specific phosphodiesterases as potential drug targets for anti-Leishmania therapy. Antimicrobial Agents and Chemotherapy, 62(10), e00603-18. (doi: 10.1128/AAC.00603-18) (PMID:30104270)

Blaazer, A. R. et al. (2018) Targeting a subpocket in Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1) enables the structure-based discovery of selective Inhibitors with trypanocidal activity. Journal of Medicinal Chemistry, 61(9), pp. 3870-3888. (doi: 10.1021/acs.jmedchem.7b01670) (PMID:29672041) (PMCID:PMC5949723)

Eze, A. A., Gould, M. K., Munday, J. C. , Tagoe, D. N.A., Stelmanis, V., Schnaufer, A. and De Koning, H. P. (2016) Reduced mitochondrial membrane potential is a late adaptation of trypanosoma brucei brucei to isometamidium preceded by mutations in the γ subunit of the F1Fo-ATPase. PLoS Neglected Tropical Diseases, 10(8), e0004791. (doi: 10.1371/journal.pntd.0004791) (PMID:27518185) (PMCID:PMC4982688)

Tagoe, D. N. A., Kalejaiye, T. D. and De Koning, H. P. (2015) The ever unfolding story of cAMP signaling in trypanosomatids: vive la difference! Frontiers in Pharmacology, 6, 185. (doi: 10.3389/fphar.2015.00185) (PMID:26441645) (PMCID:PMC4561360)

This list was generated on Thu Apr 2 08:56:57 2020 BST.