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Arendse, L. B., Danser, A. H. J., Poglitsch, M., Touyz, R. M. , Burnett Jr, J. C., Llorens-Cortes, C., Ehlers, M. R. and Sturrock, E. D. (2019) Novel therapeutic approaches targeting the renin angiotensin system and associated peptides in hypertension and heart failure. Pharmacological Reviews, (Accepted for Publication)

Rios, F. J. et al. (2019) Chanzyme TRPM7 protects against cardiovascular inflammation and fibrosis. Cardiovascular Research, (doi:10.1093/cvr/cvz164) (PMID:31250885) (Early Online Publication)

Touyz, R. M. , Anagnostopoulou, A., Rios, F. , Montezano, A. C. and Camargo, L. L. (2019) NOX5: molecular biology and pathophysiology. Experimental Physiology, 104(5), pp. 605-616. (doi:10.1113/EP086204) (PMID:30801870) (PMCID:PMC6519284)

Alves-Lopes, R., Neves, K. B. and Touyz, R. M. (2019) Muscarinic receptor type-3 (MR3) in hypertension and cholinergic-adrenergic crosstalk: genetic insights and potential for new antihypertensive targets. Canadian Journal of Cardiology, 35(5), pp. 555-557. (doi:10.1016/j.cjca.2019.02.003) (PMID:30954389) (PMCID:PMC6499128)

Neves, K. B. , Rios, F. J. , Jones, R. , Evans, T. R. J. , Montezano, A. C. and Touyz, R. M. (2019) Microparticles from vascular endothelial growth factor pathway inhibitor-treated cancer patients mediate endothelial cell injury. Cardiovascular Research, 115(5), pp. 978-988. (doi:10.1093/cvr/cvz021) (PMID:30753341) (PMCID:PMC6452312)

Bruder-Nascimento, T., Callera, G. E., Montezano, A. C., Belin de Chantemele, E. J., Tostes, R. C. and Touyz, R. M. (2019) Atorvastatin inhibits pro-inflammatory actions of aldosterone in vascular smooth muscle cells by reducing oxidative stress. Life Sciences, 221, pp. 29-34. (doi:10.1016/j.lfs.2019.01.043) (PMID:30721707)

Touyz, R. M. and Camargo, L. L. (2019) Microglia, the missing link in the brain-gut-hypertension axis. Circulation Research, 124(5), pp. 671-673. (doi:10.1161/CIRCRESAHA.119.314718) (PMID:30817265)

Touyz, R. M. , Anagnostopoulou, A., Camargo, L. L., Rios, F. J. and Montezano, A. C. (2019) Vascular biology of superoxide-generating NADPH oxidase 5 (Nox5)- implications in hypertension and cardiovascular disease. Antioxidants and Redox Signaling, 30(7), pp. 1027-1040. (doi:10.1089/ars.2018.7583) (PMID:30334629) (PMCID:PMC6354601)

Dobbin, S. J.H. , Cameron, A. C., Petrie, M. C. , Jones, R. J. , Touyz, R. M. and Lang, N. N. (2018) Toxicity of cancer therapy: what the cardiologist needs to know about angiogenesis inhibitors. Heart, 104(24), pp. 1995-2002. (doi:10.1136/heartjnl-2018-313726) (PMID:30228246) (PMCID:PMC6268130)

Neves, K. B. , Nguyen Dinh Cat, A., Alves-Lopes, R. , Harvey, K. Y., da Costa, R. M., Lobato, N. S., Montezano, A. C., Oliveira, A. M., Touyz, R. M. and Tostes, R. C. (2018) Chemerin receptor blockade improves vascular function in diabetic obese mice via redox-sensitive- and Akt-dependent pathways. American Journal of Physiology: Heart and Circulatory Physiology, 315(6), H1851-H1860. (doi:10.1152/ajpheart.00285.2018) (PMID:30216119)

Alves-Lopes, R. and Touyz, R. M. (2018) PARP-1 (poly[ADP-ribose] polymerase-1): a novel target in aortic aneurysm. Hypertension, 72(5), pp. 1087-1089. (doi:10.1161/HYPERTENSIONAHA.118.11830) (PMID:30354832) (PMCID:PMC6218001)

Camargo, L. L. et al. (2018) Vascular Nox (NADPH oxidase) compartmentalization, protein hyperoxidation, and endoplasmic reticulum stress response in hypertension. Hypertension, 72(1), pp. 235-246. (doi:10.1161/HYPERTENSIONAHA.118.10824) (PMID:29844144)

Montezano, A. C. et al. (2018) NADPH oxidase 5 is a pro‐contractile Nox isoform and a point of cross‐talk for calcium and redox signaling‐implications in vascular function. Journal of the American Heart Association, 7(12), e009388. (doi:10.1161/JAHA.118.009388) (PMID:29907654) (PMCID:PMC6220544)

Touyz, R. M. , Herrmann, S. M.S. and Herrmann, J. (2018) Vascular toxicities with VEGF inhibitor therapies-focus on hypertension and arterial thrombotic events. Journal of the American Society of Hypertension, 12(6), pp. 409-425. (doi:10.1016/j.jash.2018.03.008) (PMID:29703600) (PMCID:PMC6168784)

Touyz, R. M. and Herrmann, J. (2018) Cardiotoxicity with vascular endothelial growth factor inhibitor therapy. npj Precision Oncology, 2(1), 13. (doi:10.1038/s41698-018-0056-z)

Petrie, J. R. , Guzik, T. J. and Touyz, R. M. (2018) Diabetes, hypertension, and cardiovascular disease: clinical insights and vascular mechanisms. Canadian Journal of Cardiology, 34(5), pp. 575-584. (doi:10.1016/j.cjca.2017.12.005) (PMID:29459239) (PMCID:PMC5953551)

Neves, K. B. , Rios, F. J. , Van Der Mey, L., Alves-Lopes, R. , Cameron, A. C., Volpe, M., Montezano, A. C., Savoia, C. and Touyz, R. M. (2018) VEGFR (vascular endothelial growth factor receptor) inhibition induces cardiovascular damage via redox-sensitive processes. Hypertension, 71(4), pp. 638-647. (doi:10.1161/HYPERTENSIONAHA.117.10490) (PMID:29483228)

Nguyen Dinh Cat, A. et al. (2018) Vascular dysfunction in obese diabetic db/db mice involves the interplay between aldosterone/mineralocorticoid receptor and Rho kinase signaling. Scientific Reports, 8, 2952. (doi:10.1038/s41598-018-21087-5) (PMID:29440699) (PMCID:PMC5811612)

Almabrouk, T. A.M. , White, A. D., Ugusman, A. B., Skiba, D. S., Katwan, O. J., Alganga, H., Guzik, T. J., Touyz, R. M. , Salt, I. P. and Kennedy, S. (2018) High fat diet attenuates the anticontractile activity of aortic PVAT via a mechanism involving AMPK and reduced adiponectin secretion. Frontiers in Physiology, 9, 51. (doi:10.3389/fphys.2018.00051) (PMID:29479319) (PMCID:PMC5812172)

Valinsky, W. C., Touyz, R. M. and Shrier, A. (2018) Aldosterone, SGK1, and ion channels in the kidney. Clinical Science, 132(2), pp. 173-183. (doi:10.1042/CS20171525) (PMID:29352074)

Touyz, R. M. and Montezano, A. C. (2018) Angiotensin-(1–7) and vascular function: the clinical context. Hypertension, 71(1), pp. 68-69. (doi:10.1161/HYPERTENSIONAHA.117.10406) (PMID:29203630)

Savoia, C., Volpe, M., Grassi, G., Borghi, C., Rosei, E. A. and Touyz, R. M. (2017) Personalized medicine—a modern approach for the diagnosis and management of hypertension. Clinical Science, 131(22), pp. 2671-2685. (doi:10.1042/CS20160407) (PMID:29109301) (PMCID:PMC5736921)

Zhang, K., Zhang, Y., Feng, W., Chen, R., Chen, J., Touyz, R. M. , Wang, J. and Huang, H. (2017) Interleukin-18 enhances vascular calcification and osteogenic differentiation of vascular smooth muscle cells through TRPM7 channel activation. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(10), pp. 1933-1943. (doi:10.1161/ATVBAHA.117.309161) (PMID:28860220)

Valinsky, W. C., Touyz, R. M. and Shrier, A. (2017) Characterization of constitutive and acid-induced outwardly rectifying chloride currents in immortalized mouse distal tubular cells. Biochimica et Biophysica Acta: General Subjects, 1861(8), pp. 2007-2019. (doi:10.1016/j.bbagen.2017.05.004) (PMID:28483640) (PMCID:PMC5482324)

Hood, K. Y., Mair, K. M., Harvey, A. P., Montezano, A. C., Touyz, R. M. and MacLean, M. R. (2017) Serotonin signaling through the 5-HT1B receptor and NADPH oxidase 1 in pulmonary arterial hypertension. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(7), pp. 1361-1370. (doi:10.1161/ATVBAHA.116.308929) (PMID:28473438) (PMCID:PMC5478178)

Lucas-Herald, A. K. , Alves-Lopes, R. , Montezano, A. C., Ahmed, S. F. and Touyz, R. M. (2017) Genomic and non-genomic effects of androgens in the cardiovascular system: clinical implications. Clinical Science, 131(13), pp. 1405-1418. (doi:10.1042/CS20170090) (PMID:28645930) (PMCID:PMC5736922)

Harvey, A. P., Montezano, A. C., Hood, K. Y., Lopes, R. A. , Rios, F. , Ceravolo, G., Graham, D. and Touyz, R. M. (2017) Vascular dysfunction and fibrosis in stroke-prone spontaneously hypertensive rats: the aldosterone-mineralocorticoid receptor-Nox1 Axis. Life Sciences, 179, pp. 110-119. (doi:10.1016/j.lfs.2017.05.002) (PMID:28478264) (PMCID:5446265)

Touyz, R. M. , Montezano, A. C., Rios, F. , Widlansky, M. E. and Liang, M. (2017) Redox stress defines the small artery vasculopathy of hypertension: how do we bridge the bench-to-bedside gap? Circulation Research, 120(11), pp. 1721-1723. (doi:10.1161/CIRCRESAHA.117.310672) (PMID:28546356)

Friederich-Persson, M., Nguyen Dinh Cat, A., Persson, P., Montezano, A. C. and Touyz, R. M. (2017) Brown adipose tissue regulates small artery function through NADPH oxidase 4-derived hydrogen peroxide and redox-sensitive protein kinase G-1α. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(3), pp. 455-465. (doi:10.1161/atvbaha.116.308659) (PMID:28062507)

Mancini, S. J., White, A. D., Bijland, S., Rutherford, C., Graham, D. , Richter, E. A., Viollet, B., Touyz, R. M. , Palmer, T. M. and Salt, I. P. (2017) Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptorassociated kinase-4 phosphorylation. Molecular and Cellular Endocrinology, 440, pp. 44-56. (doi:10.1016/j.mce.2016.11.010) (PMID:27840174) (PMCID:PMC5228585)

Callera, G. E., Antunes, T. T., He, Y., Montezano, A. C., Yogi, A., Savoia, C. and Touyz, R. M. (2016) c-Src inhibition improves cardiovascular function but not remodeling or fibrosis in Ang II-induced hypertension. Hypertension, 68(5), pp. 1179-1190. (doi:10.1161/HYPERTENSIONAHA.116.07699) (PMID:27620391)

Callera, G. et al. (2016) Differential renal effects of candesartan at high-and ultra-high doses in diabetic mice: potential role of  ACE2/AT2R/Mas. Bioscience Reports, 36(5), e00398. (doi:10.1042/BSR20160344) (PMID:27612496) (PMCID:PMC5091470)

Alves-Lopes, R. , Neves, K. B. , Montezano, A., Harvey, A., Carneiro, F. S., Touyz, R. and Tostes, R. C. (2016) Internal pudendal artery dysfunction in diabetes is mediated by Nox1-derived Ros, NRF2- and RHO kinase-depedent mechanisms. Hypertension, 68(4), pp. 1056-1064. (doi:10.1161/HYPERTENSIONAHA.116.07518) (PMID:27528061)

Bruder-Nascimento, T. et al. (2016) Renoprotective effects of atorvastatin in diabetic mice: downregulation of RhoA and upregulation of Akt/GSK3. PLoS ONE, 11(9), e0162731. (doi:10.1371/journal.pone.0162731) (PMID:27649495) (PMCID:PMC5029810)

Valinsky, W. C., Jolly, A., Miquel, P., Touyz, R. M. and Shrier, A. (2016) Aldosterone upregulates transient receptor potential melastatin 7 (TRPM7). Journal of Biological Chemistry, 291(38), pp. 20163-20172. (doi:10.1074/jbc.M116.735175) (PMID:27466368) (PMCID:PMC5025699)

Hood, K. Y., Montezano, A. C., Harvey, A. P., Nilsen, M., MacLean, M. R. and Touyz, R. M. (2016) Nicotinamide adenine dinucleotide phosphate oxidase–mediated redox signaling and vascular remodeling by 16α-hydroxyestrone in human pulmonary artery cells. Hypertension, 68(3), pp. 796-808. (doi:10.1161/HYPERTENSIONAHA.116.07668) (PMID:27402919) (PMCID:PMC4978604)

Griendling, K. K., Touyz, R. M. , Zweier, J. L., Dikalov, S., Chilian, W., Yeong-Renn, C., Harrison, D. G. and Bhatnagar, A. (2016) Measurement of reactive oxygen species, reactive nitrogen species, and redox-dependent signaling in the cardiovascular system: a scientific statement from the American heart association. Circulation Research, 119(5), e39-e75. (doi:10.1161/RES.0000000000000110) (PMID:27418630) (PMCID:PMC5446086)

Weber, M. A., Poulter, N. R., Schutte, A. E., Burrell, L. M., Horiuchi, M., Prabhakaran, D., Ramirez, A. J., Wang, J.-G., Schiffrin, E. L. and Touyz, R. (2016) Is it time to reappraise blood pressure thresholds and targets? Statement from the international society of hypertension - a global perspective. Hypertension, 68(2), pp. 266-268. (doi:10.1161/HYPERTENSIONAHA.116.07818) (PMID:27354426)

Touyz, R. (2016) Lower is better in hypertension, but how low should blood pressure be targeted? Journal of the American Society of Hypertension, 10(8), pp. 621-622. (doi:10.1016/j.jash.2016.06.028) (PMID:27436128) (PMCID:PMC4990139)

Harvey, A., Montezano, A. C., Lopes, R. A. , Rios, F. and Touyz, R. (2016) Vascular fibrosis in aging and hypertension: molecular mechanisms and clinical implications. Canadian Journal of Cardiology, 32(5), pp. 659-668. (doi:10.1016/j.cjca.2016.02.070) (PMID:27118293) (PMCID:PMC4906153)

Rios, F. J. , Lopes, R. A. , Neves, K. B., Camargo, L. L., Montezano, A. C. and Touyz, R. M. (2016) Off-target vascular effects of cholesteryl ester transfer protein inhibitors involve redox-sensitive and signal transducer and activator of transcription 3-dependent pathways. Journal of Pharmacology and Experimental Therapeutics, 357(2), pp. 415-422. (doi:10.1124/jpet.115.230748) (PMID:26941168)

Nguyen Dinh Cat, A. et al. (2016) Adipocyte-specific mineralocorticoid receptor overexpression in mice is associated with metabolic syndrome and vascular dysfunction: role of redox-sensitive PKG-1 and Rho kinase. Diabetes, 65(8), pp. 2392-2403. (doi:10.2337/db15-1627) (PMID:27207514)

Touyz, R. M. and Dominiczak, A. F. (2016) Hypertension guidelines: is it time to reappraise blood pressure thresholds and targets? Hypertension, 67(4), pp. 688-689. (doi:10.1161/hypertensionaha.116.07090) (PMID:26962205)

Antunes, T. T., Callera, G. E., He, Y., Yogi, A., Ryazanov, A. G., Ryazanov, L. V., Zhai, A., Stewart, D. J., Shrier, A. and Touyz, R. (2016) Transient receptor potential melastatin 7 cation channel kinase new player in angiotensin II–induced hypertension. Hypertension, 67, pp. 763-773. (doi:10.1161/HYPERTENSIONAHA.115.07021) (PMID:26928801) (PMCID:PMC4786473)

Rios, F. J. , Harvey, A., Lopes, R. A. , Montezano, A. C. and Touyz, R. (2016) Progenitor cells, bone marrow–derived fibrocytes and endothelial-to-mesenchymal transition: new players in vascular fibrosis. Hypertension, 67, pp. 272-274. (doi:10.1161/HYPERTENSIONAHA.115.06220) (PMID:26693817)

Touyz, R. (2016) Protecting the heart in obesity: role of ACE2 and Its partners. Diabetes, 65(1), pp. 19-21. (doi:10.2337/dbi15-0014) (PMID:26696636)

Burger, D., Turner, M., Munkonda, M. N. and Touyz, R. M. (2016) Endothelial microparticle-derived reactive oxygen species: role in endothelial signaling and vascular function. Oxidative Medicine and Cellular Longevity, 2016, 5047954. (doi:10.1155/2016/5047954) (PMID:27313830) (PMCID:PMC4893592)

Cameron, A. C., Touyz, R. M. and Lang, N. N. (2015) Vascular complications of cancer chemotherapy. Canadian Journal of Cardiology, 32(7), pp. 852-862. (doi:10.1016/j.cjca.2015.12.023) (PMID:26968393) (PMCID:PMC4989034)

Lopes, R. , Neves, K. , Tostes, R., Montezano, A. and Touyz, R. (2015) Downregulation of nuclear factor erythroid 2–related factor and associated antioxidant genes contributes to redox-sensitive vascular dysfunction in hypertension. Hypertension, 2015(66), pp. 1240-1250. (doi:10.1161/hypertensionaha.115.06163) (PMID:26503970)

Montezano, A. C., Tsiropoulou, S., Dulak-Lis, M., Harvey, A., Camargo, L. D. L. and Touyz, R. M. (2015) Redox signaling, Nox5 and vascular remodeling in hypertension. Current Opinion in Nephrology and Hypertension, 24(5), pp. 425-433. (doi:10.1097/MNH.0000000000000153) (PMID:26197203) (PMCID:PMC4727501)

Neves, K. B., Nguyen Dinh Cat, A., Lopes, R. A. M., Rios, F. J. , Anagnostopoulou, A., Lobato, N. S., de Oliveira, A. M., Tostes, R. C., Montezano, A. C. and Touyz, R. M. (2015) Chemerin regulates crosstalk between adipocytes and vascular cells through Nox. Hypertension, 66(3), pp. 657-666. (doi:10.1161/HYPERTENSIONAHA.115.05616) (PMID:26150435)

Harvey, A., Montezano, A. C. and Touyz, R. M. (2015) Vascular biology of ageing—implications in hypertension. Journal of Molecular and Cellular Cardiology, 83, pp. 112-121. (doi:10.1016/j.yjmcc.2015.04.011) (PMID:25896391) (PMCID:PMC4534766)

Rios, F. , Neves, K. B., Nguyen Dinh Cat, A., Even, S., Palacios, R. , Montezano, A. C. and Touyz, R. (2015) Cholesteryl ester-transfer protein inhibitors stimulate aldosterone biosynthesis in adipocytes through nox-dependent processes. Journal of Pharmacology and Experimental Therapeutics, 353(1), pp. 27-34. (doi:10.1124/jpet.114.221002) (PMID:25617244)

Bruder-Nascimento, T., Callera, G. E., Montezano, A. C., He, Y., Antunes, T., de Cassia Tostes, R., Touyz, R. M. and , (2013) Atorvastatin Inhibits Src/ROS-mediated Redox Sensitive And Pro-Inflammatory Actions of Aldosterone in Vascular Smooth Muscle Cells: Focus on Statins Pleiotropic Effects. Hypertension, 62(3 Sup), A488.

This list was generated on Sat Dec 7 16:56:42 2019 GMT.