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Houslay, K.F., Fertig, B.A., Christian, F., Tibbo, A.J., Ling, J., Findlay, J.E., Houslay, M.D. and Baillie, G.S. (2019) Phosphorylation of PDE4A5 by MAPKAPK2 attenuates fibrin degradation via p75 signalling. Journal of Biochemistry, 166(1), pp. 97-106. (doi:10.1093/jb/mvz016) (PMID:30859186) (PMCID:PMC6607969)

Vagena, E., Ryu, J. K., Baeza-Raja, B., Walsh, N. M., Syme, C., Day, J. P., Houslay, M. D. and Baillie, G. S. (2019) A high-fat diet promotes depression-like behavior in mice by suppressing hypothalamic PKA signaling. Translational Psychiatry, 9(1), 141. (doi:10.1038/s41398-019-0470-1) (PMID:31076569) (PMCID:PMC6510753)

Blair, C. M., Walsh, N., Littman, B. H., Marcoux, F. W. and Baillie, G. S. (2019) Targeting B-Raf inhibitor resistant melanoma with novel cell penetrating peptide disrupters of PDE8A – C-Raf. BMC Cancer, 19, 266. (PMID:30909892) (PMCID:PMC6434832)

Baeza-Raja, B. et al. (2016) p75 neurotrophin receptor regulates energy balance in obesity. Cell Reports, 14(2), pp. 255-268. (doi:10.1016/j.celrep.2015.12.028) (PMID:26748707) (PMCID:PMC4831919)

Christian, F. , Krause, E., Houslay, M. D. and Baillie, G. (2014) PKA phosphorylation of p62/SQSTM1 regulates PB1 domain interaction partner binding. Biochimica et Biophysica Acta: Molecular Cell Research, 1843(11), pp. 2765-2774. (doi:10.1016/j.bbamcr.2014.07.021) (PMID:25110345)

Weninger, S., Van Craenenbroeck, K., Cameron, R., Vandeput, F., Movsesian, M.A., Baillie, G.S. and Lefebvre, R.A. (2014) Phosphodiesterase 4 interacts with the 5-HT4(b) receptor to regulate cAMP signaling. Cellular Signalling, 26(11), pp. 2573-2582. (doi:10.1016/j.cellsig.2014.07.027) (PMID:25101859)

Brown, K.M. et al. (2013) Phosphodiesterase-8A binds to and regulates Raf-1 kinase. Proceedings of the National Academy of Sciences of the United States of America, 110(16), E1533-E1542. (doi:10.1073/pnas.1303004110)

Lee, L.C.Y., Maurice, D.H. and Baillie, G.S. (2013) Targeting protein–protein interactions within the cyclic AMP signaling system as a therapeutic strategy for cardiovascular disease. Future Medicinal Chemistry, 5(4), pp. 451-464. (doi:10.4155/fmc.12.216)

Havekes, R. et al. (2012) Gravin orchestrates protein kinase A and 2-adrenergic receptor signaling critical for synaptic plasticity and memory. Journal of Neuroscience, 32(50), pp. 18137-18149. (doi:10.1523/JNEUROSCI.3612-12.2012)

Brown, K. M., Lee, L. C.Y., Findlay, J. E., Day, J. P. and Baillie, G. S. (2012) Cyclic AMP-specific phosphodiesterase, PDE8A1, is activated by protein kinase A-mediated phosphorylation. FEBS Letters, 586(11), pp. 1631-1637. (doi:10.1016/j.febslet.2012.04.033)

Edwards, H. V., Christian, F. and Baillie, G. S. (2012) cAMP: Novel concepts in compartmentalised signalling. Seminars in Cell and Developmental Biology, 23(2), pp. 181-190. (doi:10.1016/j.semcdb.2011.09.005)

Edwards, H. V., Scott, J. D. and Baillie, G. S. (2012) PKA phosphorylation of the small heat-shock protein Hsp20 enhances its cardioprotective effects. Biochemical Society Transactions, 40(1), pp. 210-214. (doi:10.1042/BST20110673)

Wang, Q. et al. (2011) The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function. Molecular Psychiatry, 16(10), pp. 1006-1023. (doi:10.1038/mp.2010.87)

Ishizuka, K. et al. (2011) DISC1-dependent switch from progenitor proliferation to migration in the developing cortex. Nature, 473(7345), pp. 92-96. (doi:10.1038/nature09859)

MacKenzie, K. F., Wallace, D. A., Hill, E. V., Anthony, D. F., Henderson, D. J.P., Houslay, D. M., Arthur, J. S. C., Baillie, G. S. and Houslay, M. D. (2011) Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation. Biochemical Journal, 435(3), pp. 755-769. (doi:10.1042/BJ20101184)

Sin, Y.Y., Edwards, H.V., Li, X., Day, J.P., Christian, F. , Dunlop, A.J., Adams, D.R., Zaccolo, M., Houslay, M.D. and Baillie, G.S. (2011) Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)–HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes. Journal of Molecular and Cellular Cardiology, 50(5), pp. 872-883. (doi:10.1016/j.yjmcc.2011.02.006) (PMID:21334344)

Christian, F. et al. (2011) Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes. Journal of Biological Chemistry, 286(11), pp. 9079-9096. (doi:10.1074/jbc.M110.160614) (PMID:21177871) (PMCID:PMC305896)

Day, J. P. et al. (2011) Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4). Journal of Medicinal Chemistry, 54(9), pp. 3331-3347. (doi:10.1021/jm200070e)

Anthony, D.F., Sin, Y.Y., Vadrevu, S., Advant, N., Day, J.P., Byrne, A.M., Lynch, M.J., Milligan, G. , Houslay, M.D. and Baillie, G.S. (2011) β-Arrestin 1 inhibits the GAP function of ARHGAP21 so as to promote the activation of RhoA following angiotensin II type 1A receptor stimulation. Molecular and Cellular Biology, 31(5), pp. 1066-1075. (doi:10.1128/MCB.00883-10) (PMID:21173159) (PMCID:PMC3067824)

Burton, P. et al. (2010) Erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells. Biochemical Journal, 432(3), pp. 575-584. (doi:10.1042/BJ20100726)

Houslay, M. D. and Christian, F. (2010) p62 (SQSTM1) forms part of a novel, reversible aggregate containing a specific conformer of the cAMP degrading phosphodiesterase, PDE4A4. Autophagy, 6(8), pp. 1198-1200. (doi:10.4161/auto.6.8.13479)

Kim, H. W., Ha, S. H., Lee, M. N., Huston, E., Kim, D.-H., Jang, S. K., Suh, P.-G., Houslay, M. D. and Ryu, S. H. (2010) cAMP controls mTOR through regulation of the dynamic interaction between Rheb and Phosphodiesterase 4D. Molecular and Cellular Biology, 30(22), pp. 5406-5420. (doi:10.1128/MCB.00217-10)

Kim, H. W., Ha, S. H., Lee, M. N., Huston, E., Kim, D.-H., Jang, S. K., Suh, P.-G., Houslay, M. D. and Ryu, S. H. (2010) Cyclic AMP Controls mTOR through Regulation of the Dynamic Interaction between Rheb and Phosphodiesterase 4D. Molecular and Cellular Biology, 30(22), pp. 5406-5420. (doi:10.1128/MCB.00217-10)

Rampersad, S. N., Ovens, J. D., Huston, E., Umana, M. B., Wilson, L. S., Netherton, S. J., Lynch, M. J., Baillie, G. S. , Houslay, M. D. and Maurice, D. H. (2010) Cyclic AMP Phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a Vascular Endothelial Cadherin (VE-Cad)-based Signaling Complex and Controls cAMP-mediated Vascular Permeability. Journal of Biological Chemistry, 285(44), pp. 33614-33622. (doi:10.1074/jbc.M110.140004)

Christian, F. , Anthony, D. F., Vadrevu, S., Riddell, T., Day, J. P., McLeod, R., Adams, D. R., Baillie, G. S. and Houslay, M. D. (2010) p62 (SQSTM1) and cyclic AMP phosphodiesterase-4A4 (PDE4A4) locate to a novel, reversible protein aggregate with links to autophagy and proteasome degradation pathways. Cellular Signalling, 22(10), pp. 1576-1596. (doi:10.1016/j.cellsig.2010.06.003)

Zhu, H. et al. (2010) Evolutionarily Conserved Role of Calcineurin in Phosphodegron-Dependent Degradation of Phosphodiesterase 4D. Molecular and Cellular Biology, 30(18), pp. 4379-4390. (doi:10.1128/MCB.01193-09)

Serrels, B., Sandilands, E., Serrels, A., Baillie, G. , Houslay, M. D., Brunton, V. G., Canel, M., Machesky, L. M. , Anderson, K. I. and Frame, M. C. (2010) A complex between FAK, RACK1, and PDE4D5 controls spreading initiation and cancer cell polarity. Current Biology, 20(12), pp. 1086-1092. (doi:10.1016/j.cub.2010.04.042)

Li, X. et al. (2010) Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK. Biochemical Journal, 428(1), pp. 55-65. (doi:10.1042/BJ20091672)

Kelly, M. P. et al. (2010) Phosphodiesterase 11A in brain is enriched in ventral hippocampus and deletion causes psychiatric disease-related phenotypes. Proceedings of the National Academy of Sciences of the United States of America, 107(18), pp. 8457-8462. (doi:10.1073/pnas.1000730107)

Bjorgo, E., Solheim, S. A., Abrahamsen, H., Baillie, G. S. , Brown, K. M., Berge, T., Okkenhaug, K., Houslay, M. D. and Tasken, K. (2010) Cross talk between phosphatidylinositol 3-kinase and cyclic AMP (cAMP)-protein kinase A signaling pathways at the level of a protein kinase B/β-Arrestin/cAMP phosphodiesterase 4 complex. Molecular and Cellular Biology, 30(7), pp. 1660-1672. (doi:10.1128/MCB.00696-09)

Hayashi-Takagi, A. et al. (2010) Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1. Nature Neuroscience, 13(3), pp. 327-332. (doi:10.1038/nn.2487)

Houslay, M. D. (2010) Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown. Trends in Biochemical Sciences, 35(2), pp. 91-100. (doi:10.1016/j.tibs.2009.09.007)

Xu, T. et al. (2010) Inferring signaling pathway topologies from multiple perturbation measurements of specific biochemical species. Science Signaling, 3(113), ra20. (doi:10.1126/scisignal.2000517)

Vecsey, C. G. et al. (2009) Sleep deprivation impairs cAMP signalling in the hippocampus. Nature, 461(7267), pp. 1122-1125. (doi:10.1038/nature08488)

Li, X. et al. (2009) A scanning peptide array approach uncovers association sites within the JNK/βarrestin signalling complex. FEBS Letters, 583(20), pp. 3310-3316. (doi:10.1016/j.febslet.2009.09.035)

Houslay, M. D. (2009) Disrupting specific PDZ domain-mediated interactions for therapeutic benefit. British Journal of Pharmacology, 158(2), pp. 483-485. (doi:10.1111/j.1476-5381.2009.00359.x)

Kiely, P. A., Baillie, G. S. , Barrett, R., Buckley, D. A., Adams, D. R., Houslay, M. D. and O'Connor, R. (2009) Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for IGF-I-mediated regulation of focal adhesion kinase (FAK). Journal of Biological Chemistry, 284, pp. 20263-20274. (doi:10.1074/jbc.M109.017640) (PMID:19423701) (PMCID:PMC2740452)

Li, X., Baillie, G. S. and Houslay, M. D. (2009) Mdm2 directs the ubiquitination of β-arrestin-sequestered cAMP phosphodiesterase-4D5. Journal of Biological Chemistry, 284(24), pp. 16170-16182. (doi:10.1074/jbc.M109.008078)

Ong, W.K., Gribble, F.M., Reimann, F., Lynch, M.J., Houslay, M.D., Baillie, G.S. , Furman, B.L. and Pyne, N.J. (2009) The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon-like peptide-1 release. British Journal of Pharmacology, 157(4), pp. 633-644. (doi:10.1111/j.1476-5381.2009.00194.x)

Meng, D., Lynch, M. J., Huston, E., Beyermann, M., Eichhorst, J., Adams, D. R., Klusmann, E., Houslay, M. D. and Baillie, G. S. (2009) MEK1 binds directly to βArrestin1, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization. Journal of Biological Chemistry, 284(17), pp. 11425-11435. (doi:10.1074/jbc.M806395200) (PMID:19153083) (PMCID:PMC2670148)

Houslay, M. D. (2009) Arrestin times for developing antipsychotics and β-blockers. Science Signaling, 2(66), e22. (doi:10.1126/scisignal.266pe22)

Terrenoire, C., Houslay, M. D., Baillie, G. S. and Kass, R. S. (2009) The Cardiac IKs Potassium Channel Macromolecular Complex Includes the Phosphodiesterase PDE4D3. Journal of Biological Chemistry, 284(14), pp. 9140-9146. (doi:10.1074/jbc.M805366200)

Baillie, G. S. (2009) Compartmentalized signalling: spatial regulation of cAMP by the action of compartmentalized phosphodiesterases. FEBS Journal, 276(7), pp. 1790-1799. (doi:10.1111/j.1742-4658.2009.06926.x)

Collins, D. M., Murdoch, H., Dunlop, A. J., Charych, E., Baillie, G. S. , Wang, Q., Herberg, F. W., Brandon, N., Prinz, A. and Houslay, M. D. (2008) Ndel1 alters its conformation by sequestering cAMP-specific phosphodiesterase-4D3 (PDE4D3) in a manner that is dynamically regulated through Protein Kinase A (PKA). Cellular Signalling, 20(12), pp. 2356-2369. (doi:10.1016/j.cellsig.2008.09.017)

McCahill, A., Campbell, L., McSorley, T., Lynch, M. J., Li, X., Yang, C., Baillie, G. S. , Houslay, M. D. and Sood, A. (2008) In cardiac myocytes, cAMP elevation triggers the down-regulation of transcripts and promoter activity for cyclic AMP phosphodiesterase-4A10 (PDE4A10). Cellular Signalling, 20(11), pp. 2071-2083. (doi:10.1016/j.cellsig.2008.07.017)

Di Benedetto, G., Zoccarato, A., Lissandron, V., Terrin, A., Li, X., Houslay, M. D., Baillie, G. S. and Zaccolo, M. (2008) Protein kinase A type I and type II define distinct intracellular signaling compartments. Circulation Research, 103(8), pp. 836-844. (doi:10.1161/CIRCRESAHA.108.174813)

Day, J. P., Cleghon, V., Houslay, M. D. and Davies, S. A. (2008) Regulation of a Drosophila melanogaster cGMP-specific phosphodiesterase by prenylation and interaction with a prenyl-binding protein. Biochemical Journal, 414(Pt3), pp. 363-374. (doi:10.1042/BJ20080560)

Huston, E., Lynch, M. J., Mohamed, A., Collins, D. M., Hill, E. V., McLeod, R., Krause, E., Baillie, G. S. and Houslay, M. D. (2008) EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation. Proceedings of the National Academy of Sciences of the United States of America, 105(35), pp. 12791-12796. (doi:10.1073/pnas.0805167105)

Kiely, P. A., Baillie, G. S. , Lynch, M. J., Houslay, M. D. and O'Connor, R. (2008) Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and {beta}1 integrin and for tumor cell proliferation and migration. Journal of Biological Chemistry, 283(34), pp. 22952-22961. (doi:10.1074/jbc.M800802200)

Xu, T.-R., Baillie, G. S. , Bhari, N., Houslay, T. M., Pitt, A. M., Adams, D. R., Kolch, W., Houslay, M. D. and Milligan, G. (2008) Mutations of β-arrestin 2 that limit self-association also interfere with interactions with the β2-adrenoceptor and the ERK1/2 MAPKs: implications for β2-adrenoceptor signalling via the ERK1/2 MAPKs. Biochemical Journal, 413(1), pp. 51-60. (doi:10.1042/BJ20080685)

Mackenzie, K. F. et al. (2008) Human PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary change. Biochemical Journal, 411(2), pp. 361-369. (doi:10.1042/BJ20071251)

Cullen, M. D., Cheung, Y.-F., Houslay, M. D., Hartman, T. L., Watson, K. M., Buckheit, R. W., Pannecouque, C., De Clercq, E. and Cushman, M. (2008) Investigation of the alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors as potential cAMP phosphodiesterase-4B2 inhibitors. Bioorganic and Medicinal Chemistry Letters, 18(4), pp. 1530-1533. (doi:10.1016/j.bmcl.2007.12.015)

Kelly, M. P., Cheung, Y.-F., Favilla, C., Siegel, S. J., Kanes, S. J., Houslay, M. D. and Abel, T. (2008) Constitutive activation of the G-protein subunit Gαs within forebrain neurons causes PKA-dependent alterations in fear conditioning and cortical Arc mRNA expression. Learning and Memory, 15(2), pp. 75-83. (doi:10.1101/lm.723708)

McCahill, A., Huston, E., Li, X. and Houslay, M.D. (2008) PDE4 associates with different scaffolding proteins: modulating interactions as treatment for certain diseases. In: Klussman, E. and Scott, J. (eds.) Protein-Protein Interactions as New Drug Targets. Series: Handbook of Experimental Pharmacology (186). Springer: Berlin, Germany, pp. 125-166. ISBN 9783540728429 (doi:10.1007/978-3-540-72843-6_6)

Smith, K. J. et al. (2007) 1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, βarrestin and RACK1. Cellular Signalling, 19(12), pp. 2612-2624. (doi:10.1016/j.cellsig.2007.08.015)

Houslay, M. D., Lynch, M. J. and Baillie, G. S. (2007) cAMP-specific phosphodiesterase-4D5 (PDE4D5) provides a paradigm for understanding the unique non-redundant roles that PDE4 isoforms play in shaping compartmentalized cAMP cell signalling. Biochemical Society Transactions, 35(5), pp. 938-941. (doi:10.1042/BST0350938)

Smith, K. et al. (2007) H-1 NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, arrestin and RACK1. Cellular Signalling, 19, pp. 2612-2624. (doi:10.1016/j.cellsig.2007.08.015)

This list was generated on Sat Dec 7 17:10:47 2019 GMT.