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Mackenzie, K. F. et al. (2008) Human PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary change. Biochemical Journal, 411(2), pp. 361-369. (doi: 10.1042/BJ20071251)

Kelly, M. P., Cheung, Y.-F., Favilla, C., Siegel, S. J., Kanes, S. J., Houslay, M. D. and Abel, T. (2008) Constitutive activation of the G-protein subunit Gαs within forebrain neurons causes PKA-dependent alterations in fear conditioning and cortical Arc mRNA expression. Learning and Memory, 15(2), pp. 75-83. (doi: 10.1101/lm.723708)

Kelly, M. P. et al. (2007) Constitutive activation of G alpha s within forebrain neurons causes deficits in sensorimotor gating because of PKA-dependent decreases in cAMP. Neuropsychopharmacology, 32, pp. 577-588. (doi: 10.1038/sj.npp.1301099)

McEwan, D. , Brunton, V. , Baillie, G. , Leslie, N. , Houslay, M. and Frame, M. (2007) Chemoresistant KM12C colon cancer cells are addicted to low cyclic AMP levels in a phosphodiesterase 4-regulated compartment via effects on phosphoinositide 3-kinase. Cancer Research, 67, pp. 5248-5257. (doi: 10.1158/0008-5472.CAN-07-0097)

Stefan, E. et al. (2007) Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells. Journal of the American Society of Nephrology, 18, pp. 199-212. (doi: 10.1681/ASN.2006020132)

Gronning, L. M. , Baillie, G. S. , Cederberg, A. , Lynch, M. J. , Houslay, M. D. , Enerback, S. and Tasken, K. (2006) Reduced PDE4 expression and activity contributes to enhanced catecholamine-induced cAMP accumulation in adipocytes from FOXC2 transgenic mice. FEBS Letters, 580(17), pp. 4126-4130. (doi: 10.1016/j.febslet.2006.06.058)

Day, J.P., Houslay, M.D. and Davies, S.-A. (2006) A novel role for a Drosophila homologue of cGMP-specific phosphodiesterase in the active transport of cGMP. Biochemical Journal, 393(2), pp. 481-488.

Bolger, G.B. et al. (2006) Scanning peptide array analysis identify overlapping binding sites for the signaling scaffold proteins, beta-arestin and RACK1 in the cAMP-specific phosphodiesterase, PDE4D5. Biochemical Journal, 398(1), pp. 23-36. (doi: 10.1042/BJ20060423)

Huston, E., Gall, I., Houslay, T. and Houslay, M. (2006) Helix-1 of the cAMP-specific phosphodiesterase PDE4A1 regulates its phospholipase-D-dependent redistribution in response to release of Ca2+. Journal of Cell Science, 119, pp. 3799-3810. (doi: 10.1242/jcs.03106)

Houslay, M. and Baillie, G. (2006) Phosphodiesterase-4 gates the ability of protein kinase A to phosphorylate G-protein receptor kinase-2 and influence its translocation. Biochemical Society Transactions, 34, pp. 474-475.

Millen, J., MacLean, M.R. and Houslay, M.D. (2006) Hypoxia-induced remodelling of PDE4 isoform expression and cAMP handling in human pulmonary artery smooth muscle cells. European Journal of Cell Biology, 85, pp. 679-691. (doi: 10.1016/j.ejcb.2006.01.006)

Terrin, A. et al. (2006) PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases. Journal of Cell Biology, 175, pp. 441-451. (doi: 10.1083/jcb.200605050)

Lynch, M., Hill, E. and Houslay, M. (2006) Intracellular targeting of phosphodiesterase-4 underpins compartmentalized cAMP signaling. Current Topics in Developmental Biology, 75, pp. 225-259. (doi: 10.1016/S0070-2153(06)75007-4)

Hill, E., Sheppard, C., Cheung, Y., Gall, I., Krause, E. and Houslay, M. (2006) Oxidative stress employs phosphatidyl inositol 3-kinase and ERK signalling pathways to activate cAMP phosphodiesterase-4D3 (PDE4D3) through multi-site phosphorylation at Ser239 and Ser579. Cellular Signalling, 18, pp. 2056-2069. (doi: 10.1016/j.cellsig.2006.07.018)

Li, X. , Huston, E. , Lynch, M. , Houslay, M. and Baillie, G. (2006) Phosphodiesterase-4 influences the PKA phosphorylation status and membrane translocation of G-protein receptor kinase 2 (GRK2) in HEK-293 beta 2 cells and cardiac myocytes. Biochemical Journal, 394, pp. 427-435. (doi: 10.1042/BJ20051560)

Kalamidas, S. et al. (2006) cAMP synthesis and degradation by phagosomes regulate actin assembly and fusion events: consequences for mycobacteria. Journal of Cell Science, 119, pp. 3686-3694. (doi: 10.1242/jcs.03091)

McSorley, T. , Stefan, E. , Henn, V. , Wiesner, B. , Baillie, G. , Houslay, M. , Rosenthal, W. and Klussmann, E. (2006) Spatial organisation of AKAP18 and PDE4 isoforms in renal collecting duct principal cells. European Journal of Cell Biology, 85, pp. 673-678. (doi: 10.1016/j.ejcb.2006.01.005)

Mongillo, M. et al. (2006) Compartmentalized phosphodiesterase-2 activity blunts beta-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway. Circulation Research, 98, pp. 226-234. (doi: 10.1161/01.RES.0000200178.34179.93)

Huston, E. , Houslay, T. , Baillie, G. and Houslay, M. (2006) cAMP phosphodiesterase-4A1 (PDE4A1) has provided the paradigm for the intracellular targeting of phosphodiesterases, a process that underpins compartmentalized cAMP signalling. Biochemical Society Transactions, 34, pp. 504-509.

Houslay, M. (2006) A RSK(y) relationship with promiscuous PKA. STKE, 2006(349 pe), pp. 1-5. (doi: 10.1126/stke.3492006pe32)

Baillie, G. S. , Scott, J. D. and Houslay, M. D. (2005) Compartmentalisation of phosphodiesterases and protein kinase A: opposites attract. FEBS Letters, 579(15), pp. 3264-3270. (doi: 10.1016/j.febslet.2005.03.089)

Lynch, M. , Baillie, G. , Mohamed, A. , Li, X. , Maisonneuve, C. , Klussmann, E. , van Heeke, G. and Houslay, M. (2005) RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta(2)-adrenergic receptor to activation of ERK in HEK293B2 cells. Journal of Biological Chemistry, 280, pp. 33178-33189. (doi: 10.1074/jbc.M414316200)

Houslay, M. and Baillie, G. (2005) beta-Arrestin-recruited phosphodiesterase-4 desensitizes the AKAP79/PKA-mediated switching of beta(2)-adrenoceptor signalling to activation of ERK. Biochemical Society Transactions, 33, pp. 1333-1336.

Baillie, G. and Houslay, M. (2005) Arrestin times for compartmentalised cAMP signalling and phosphodiesterase-4 enzymes. Current Opinion in Cell Biology, 17, pp. 129-134. (doi: 10.1016/

Wallace, D. et al. (2005) Identification and characterization of PDE4A11, a novel, widely expressed long isoform encoded by the human PDE4A cAMP phosphodiesterase gene. Molecular Pharmacology, 67, pp. 1920-1934. (doi: 10.1124/mol.104.009423)

Henn, V. , Stefan, E. , Baillie, G. , Houslay, M. , Rosenthal, W. and Klussmann, E. (2005) Compartmentalized cAMP signalling regulates vasopressin-mediated water reabsorption by controlling aquaporin-2. Biochemical Society Transactions, 33, pp. 1316-1318.

McCahill, A. et al. (2005) In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase - A type II located in the centrosomal region. Cellular Signalling, 17, pp. 1158-1173. (doi: 10.1016/j.cellsig.2005.04.003)

Millar, J. et al. (2005) DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling. Science, 310, pp. 1187-1191. (doi: 10.1126/science.1112915)

Day, J. , Dow, J. , Houslay, M. and Davies, S. (2005) Cyclic nucleotide phosphodiesterases in Drosophila melanogaster. Biochemical Journal, 388, pp. 333-342. (doi: 10.1042/BJ20050057)

Houslay, M. (2005) Keynote review: Phosphodiesterase-4 as a therapeutic target. Drug Discovery Today, 10(22), pp. 1503-1519. (doi: 10.1016/S1359-6446(05)03622-6)

Fleming, Y., Frame, M. and Houslay, M. (2004) PDE4-regulated cAMP degradation controls the assembly of integrin-dependent actin adhesion structures and REF52 cell migration. Journal of Cell Science, 117, pp. 2377-2388. (doi: 10.1242/jcs.01096)

Abrahamsen, H. , Baillie, G. , Ngai, J. , Vang, T. , Nika, K. , Ruppelt, A. , Mustelin, T. , Zaccolo, M. , Houslay, M. and Tasken, K. (2004) TCR- and CD28-mediated recruitment of phosphodiesterase 4 to lipid rafts potentiates TCR signaling. Journal of Immunology, 173, pp. 4847-4858.

Barber, R. , Baillie, G.S. , Bergmann, R. , Shepherd, M.C. , Sepper, R. , Houslay, M.D. and Van Heeke, G. (2004) Differential expression of PDE4 cAMP phosphodiesterase isoforms in inflammatory cells of smokers with COPD, smokers without COPD, and nonsmokers. American Journal of Physiology: Lung Cellular and Molecular Physiology, 287, L332-L343. (doi: 10.1152/ajplung.00384.2003)

Johnston, L. et al. (2004) Expression, intracellular distribution and basis for lack of catalytic activity of the PDE4A7 isoform encoded by the human PDE4A cAMP-specific phosphodiesterase gene. Biochemical Journal, 380, pp. 371-384.

MacPherson, M. , Broderick, K. , Graham, S. , Day, J. , Houslay, M. , Dow, J. and Davies, S. (2004) The dg2 (for) gene confers a renal phenotype in Drosophila by modulation of cGMP-specific phosphodiesterase. Journal of Experimental Biology, 207, pp. 2769-2776. (doi: 10.1242/jeb.01086)

Mongillo, M. et al. (2004) Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases. Circulation Research, 95, pp. 67-75. (doi: 10.1161/01.RES.0000134629.84732.11)

Shepherd, M. , Baillie, G. , Stirling, D. and Houslay, M. (2004) Remodelling of the PDE4 cAMP phosphodiesterase isoform profile upon monocyte-macrophage differentiation of human U937 cells. British Journal of Pharmacology, 142, pp. 339-351. (doi: 10.1038/sj.bjp.0705770)

This list was generated on Tue Sep 29 16:28:22 2020 BST.