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Scarpa, M. et al. (2021) Biased M1 muscarinic receptor mutant mice show accelerated progression of prion neurodegenerative disease. Proceedings of the National Academy of Sciences of the United States of America, 118(50), e2107389118. (doi: 10.1073/pnas.2107389118) (PMID:34893539) (PMCID:PMC8685681)

Brown, A. J.H. et al. (2021) From structure to clinic: design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer’s disease. Cell, 184(24), 5886-5901.e22. (doi: 10.1016/j.cell.2021.11.001) (PMID:34822784)

Burger, W. A. C. et al. (2021) Identification of a novel allosteric site at the M5 muscarinic acetylcholine receptor. ACS Chemical Neuroscience, 12(16), pp. 3112-3123. (doi: 10.1021/acschemneuro.1c00383) (PMID:34351123)

Scammells, P. J. et al. (2021) Development of novel 4‐arylpyridin‐2‐one and 6‐arylpyrimidin‐4‐one positive allosteric modulators of the M1 muscarinic acetylcholine receptor. ChemMedChem, 16(1), pp. 216-233. (doi: 10.1002/cmdc.202000540) (PMID:32851779)

Thompson, K. J. and Tobin, A. B. (2020) Crosstalk between the M1 muscarinic acetylcholine receptor and the endocannabinoid system: A relevance for Alzheimer's disease? Cellular Signalling, 70, 109545. (doi: 10.1016/j.cellsig.2020.109545) (PMID:31978506) (PMCID:PMC7184673)

Bradley, S. J. et al. (2020) Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs. Nature Chemical Biology, 16(3), pp. 240-249. (doi: 10.1038/s41589-019-0453-9) (PMID:32080630)

Khajehali, E., Bradley, S. , van der Westhuizen, E. T., Molloy, C. , Valant, C., Finlayson, L. , Lindsley, C. W., Sexton, P. M., Tobin, A. B. and Christopoulos, A. (2020) Restoring agonist function at a chemogenetically modified M1 muscarinic acetylcholine receptor. ACS Chemical Neuroscience, 11(24), pp. 4270-4279. (doi: 10.1021/acschemneuro.0c00540) (PMID:33196174)

Vuckovic, Z. et al. (2019) Crystal structure of the M5 muscarinic acetylcholine receptor. Proceedings of the National Academy of Sciences of the United States of America, 116(51), pp. 26001-26007. (doi: 10.1073/pnas.1914446116) (PMID:31772027) (PMCID:PMC6926013)

Jörg, M. et al. (2019) 6-Phenylpyrimidin-4-ones as positive allosteric modulators at the M1 mAChR: the determinants of allosteric activity. ACS Chemical Neuroscience, 10(3), pp. 1099-1114. (doi: 10.1021/acschemneuro.8b00613) (PMID:30547573)

This list was generated on Mon May 16 14:54:37 2022 BST.