Hao, D., Hu, C. , Grant, J. , Glidle, A. and Cumming, D. R.S. (2018) Hybrid localized surface plasmon resonance and quartz crystal microbalance sensor for label free biosensing. Biosensors and Bioelectronics, 100, pp. 23-27. (doi: 10.1016/j.bios.2017.08.038) (PMID:28850824)
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Abstract
We report on the design and fabrication of a hybrid sensor that integrates transmission-mode localized surface plasmonic resonance (LSPR) into a quartz crystal microbalance (QCM) for studying biochemical surface reactions. The coupling of LSPR nanostructures and a QCM allows optical spectra and QCM resonant frequency shifts to be recorded simultaneously and analyzed in real time for a given surface adsorption process. This integration simplifies the conventional combination of SPR and QCM and has the potential to be miniaturized for application in point-of-care (POC) diagnostics. The influence of antibody-antigen recognition effect on both the QCM and LSPR has been analyzed and discussed.``
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Cumming, Professor David and Glidle, Dr Andrew and Hao, Danni and Grant, Dr James and Hu, Dr Chunxiao |
| Authors: | Hao, D., Hu, C., Grant, J., Glidle, A., and Cumming, D. R.S. |
| College/School: | College of Science and Engineering > School of Engineering > Biomedical Engineering College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering |
| Journal Name: | Biosensors and Bioelectronics |
| Publisher: | Elsevier |
| ISSN: | 0956-5663 |
| ISSN (Online): | 1873-4235 |
| Published Online: | 31 August 2017 |
| Copyright Holders: | Copyright © 2017 Elsevier B.V. |
| First Published: | First published in Biosensors and Bioelectronics 100:23-27 |
| Publisher Policy: | Reproduced under a Creative Commons License |
| Data DOI: | 10.5525/gla.researchdata.447 |
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