Clark, J. S. , Romiti, F., Hogg, K. F., Hamid, M. H. S. A., Richter, S. C., Boyer, A. , Redman, J. C. and Farrugia, L. J. (2015) Synthesis of cyclopropyl-substituted furans by Brønsted acid promoted cascade reactions. Angewandte Chemie (International Edition), 54(19), pp. 5744-5747. (doi: 10.1002/anie.201500625) (PMID:25782604)
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Abstract
Chloroacetic acid promotes an efficient and diastereoselective intramolecular cascade reaction of electron-deficient ynenones to deliver products featuring a 2,3,5-trisubstituted furan bearing a fused cyclopropyl substituent at the 5-position. Synthetically relevant polycyclic building blocks featuring rings of various sizes and heteroatoms have been synthesized in high yield using this mild acid-catalyzed reaction.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Hamid, Dr Malai Haniti Sh and Boyer, Dr Alistair and Clark, Professor Stephen and Farrugia, Dr Louis |
| Authors: | Clark, J. S., Romiti, F., Hogg, K. F., Hamid, M. H. S. A., Richter, S. C., Boyer, A., Redman, J. C., and Farrugia, L. J. |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | Angewandte Chemie (International Edition) |
| Publisher: | Wiley-VCH Verlag GmbH &Co. KGaA |
| ISSN: | 1433-7851 |
| ISSN (Online): | 1521-3773 |
| Copyright Holders: | Copyright © 2015 Wiley-VCH Verlag GmbH & Co. KGaA |
| First Published: | First published in Angewandte Chemie (International Edition) 54(19):5744-5747 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher. |
| Data DOI: | 10.5525/gla.researchdata.166 |
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