A common proviral integration region, fit-1, in t-cell tumors induced by myc-containing feline leukemia viruses

Tsujimoto, H. et al. (1993) A common proviral integration region, fit-1, in t-cell tumors induced by myc-containing feline leukemia viruses. Virology, 196(2), pp. 845-848. (doi: 10.1006/viro.1993.1544)

Abstract

Feline leukemia viruses carrying transduced v-myc genes (myc-FeLV) induce tumors of clonel origin, suggesting that activated myc alone is not sufficient for tumorgenesis. To investigate the hypothesis that insertional mutagenesis plays a role by activating genes which collaborate with v-myc, we looked for evidence of common proviral integration sites in these tumors. By inverse polymerase chain reaction we identified a 6-kb domain, designated fit-1, in which FeLV proviruses were inserted in four of nine (44%) T-cell tumors induced by myc-FeLV. The fit-1 locus was mapped to feline chromosome B2 and appears to be distinct from known oncogenes located on this chromosome. Fit-1 represents a novel common proviral integration region which may harbor a cellular gene which acts in concert with the myc gene in T-cell tumorigenesis.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Fulton, Dr Ruth and Neil, Professor James and Onions, Professor David and Terry, Mrs Anne
• Authors: Tsujimoto, H., Fulton, R., Nishigaki, K., Matsumoto, Y., Hasegawa, A., Tsujimoto, A., Cevario, S., O'Brien, S. J., Terry, A., Onions, D., and Neil, J. C.
• College/School: College of Medical Veterinary and Life Sciences > School of Life Sciences; College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Virology
• Publisher: Elsevier
• ISSN: 0042-6822
• ISSN (Online): 1096-0341