Feline leukaemia virus: generation of pathogenic and oncogenic variants

Neil, J. C. , Fulton, R., Rigby, M. and Stewart, M. (1991) Feline leukaemia virus: generation of pathogenic and oncogenic variants. In: Kung, H.-J. and Vogt, P. K. (eds.) Retroviral Insertion and Oncogene Activation. Series: Current Topics in Microbiology and Immunology, 171 (171). Springer Berlin Heidelberg, pp. 67-93. (doi:10.1007/978-3-642-76524-7_4)

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Publisher's URL: http://dx.doi.org/10.1007/978-3-642-76524-7_4

Abstract

Although feline leukaemia virus (FeLV) is a common and potent pathogen of the domestic cat, neoplastic disease is a relatively rare outcome of the virus-host interaction and generally occurs after a long latent period (Hardy et al. 1976; Jarrett 1984). For these reasons, it has been customary to classify FeLV as a chronic leukaemogenic retrovirus and to place the acute transforming C-type retroviruses in a separate subclass. In our view, this classification has been unhelpful since it obscures the fact that acute transforming retroviruses invariably arise from the chronic leukaemogenic variety. Moreover, there is mounting evidence that terminal diseases which develop in FeLV-infected cats are induced by variant genomes that arise de novo. In this review, we discuss the origins of FeLV variants and briefly consider their roles in disease.

Item Type:Book Sections
Status:Published
Glasgow Author(s) Enlighten ID:Fulton, Dr Ruth and Neil, Professor James
Authors: Neil, J. C., Fulton, R., Rigby, M., and Stewart, M.
College/School:College of Medical Veterinary and Life Sciences > School of Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Publisher:Springer Berlin Heidelberg
ISSN:0070-217X

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