Receptor-mediated leukaemogenesis: hypothesis revisited

Neil, J.C. , Fulton, R., McFarlane, R., Rigby, M., Stewart, M., Terry, A. and Tzavaras, T. (1988) Receptor-mediated leukaemogenesis: hypothesis revisited. British Journal of Cancer, 58(Sup IX), pp. 76-79.

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The discovery of the first example of retroviral transduction of an immunological effector molecule has led us to reconsider the possible importance of cell surface receptors of the immune system in leukaemia development. Antigen receptors on lymphoid cells not only bind external ligands but are crucial in the control of cellular proliferation. The concept of autocrine stimulation in oncogenesis is already well established and we see no reason to exclude the possibility of the analogous mechanism operating through antigen receptors. At present, we are investigating the oncogenic function of the retrovirus (FeLV-T17) carrying a T-cell receptor gene (v-tcr). In addressing the general concept of oncogenesis by ligand/receptor interactions in the immune system we face the problem of the diversity and, for T-cell antigen receptors, the complex nature of receptor-ligand interaction. Nevertheless, the wide implications of the model encourage us to continue to search for new experimental tools and approaches to the question.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Fulton, Dr Ruth and Neil, Professor James and McFarlane, Mr Robert and Terry, Mrs Anne
Authors: Neil, J.C., Fulton, R., McFarlane, R., Rigby, M., Stewart, M., Terry, A., and Tzavaras, T.
College/School:College of Medical Veterinary and Life Sciences > School of Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:British Journal of Cancer
Publisher:Nature Publishing Group
ISSN (Online):1532-1827
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