Polarised cell migration: intrinsic and extrinsic drivers

Woodham, E. F. and Machesky, L. M. (2014) Polarised cell migration: intrinsic and extrinsic drivers. Current Opinion in Cell Biology, 30, pp. 25-32. (doi:10.1016/j.ceb.2014.05.006)

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Abstract

Cell polarity arises out of asymmetry of the distribution and organisation of cell contents. Polarity is an important feature of all living organisms and much energy is devoted to breaking symmetry and establishing polarity. Recent developments in our understanding of how the budding yeast Saccharomyces cerevisiae establishes and maintains polarity for cell division shed light on universal mechanisms that may be relevant to both asymmetric cell division and polarised cell migration in other organisms. Here, we summarise some of the recent developments in our understanding of polarity of the cytoskeleton and associated signalling molecules as it relates to cell migration. Parallels are drawn between planar cell polarity and apical-basal polarity in epithelial tissues and front-back polarity in migrating cells.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Machesky, Professor Laura
Authors: Woodham, E. F., and Machesky, L. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Current Opinion in Cell Biology
Publisher:Elsevier Ltd.
ISSN:0955-0674
ISSN (Online):1879-0410

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