Germ-line transmitted, chromosomally integrated hhv-6 and classical Hodgkin lymphoma

Bell, A. J., Gallagher, A., Mottram, T., Lake, A., Kane, E. V., Lightfoot, T., Roman, E. and Jarrett, R. F. (2014) Germ-line transmitted, chromosomally integrated hhv-6 and classical Hodgkin lymphoma. PLoS ONE, 9(11), e112642. (doi:10.1371/journal.pone.0112642) (PMID:25384040) (PMCID:PMC4226568)

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Publisher's URL: http://dx.doi.org/10.1371/journal.pone.0112642

Abstract

A unique feature of both human herpesvirus 6A and B (HHV-6A and B) among human herpesviruses is their ability to integrate into chromosomal telomeres. In some individuals integrated viral genomes are present in the germ-line and result in the vertical transmission of HHV-6; however, little is known about the disease associations of germ-line transmitted, chromosomally integrated HHV-6 (ciHHV-6). Recent publications suggest that HHV-6 is associated with classical Hodgkin lymphoma (cHL). Here we examine the prevalence of ciHHV-6 in 936 cases of cHL and 563 controls by screening with a duplex TaqMan assay and confirming with droplet digital PCR. ciHHV-6 was detected in 10/563 (1.8%) controls and in all but one individual the virus was HHV-6B. Amongst cases 16/936 (1.7%) harboured ciHHV-6, thus demonstrating no association between ciHHV-6 and risk of cHL.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Jarrett, Professor Ruth and Gallagher, Dr Alice and Mottram, Mr Timothy and Lake, Ms Annette
Authors: Bell, A. J., Gallagher, A., Mottram, T., Lake, A., Kane, E. V., Lightfoot, T., Roman, E., and Jarrett, R. F.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:PLoS ONE
Publisher:Public Library of Science
ISSN:1932-6203
Copyright Holders:Copyright © 2014 The Authors
First Published:First published in PLoS ONE 9(11):e112642
Publisher Policy:Reproduced under a Creative Commons License
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
501443Centre for Integrated VirologyMassimo PalmariniMedical Research Council (MRC)G0801822/1MVLS III - CENTRE FOR VIRUS RESEARCH