Keith, W.N. , Evans, T.R.J. and Glasspool, R.M. (2001) Telomerase and cancer: time to move from a promising target to a clinical reality. Journal of Pathology, 195(4), pp. 404-414. (doi: 10.1002/path.1001)
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Publisher's URL: http://dx.doi.org/10.1002/path.1001
Abstract
The past 25 years have seen unparalleled advances in our understanding of the molecular basis of cancer. As a result, novel molecular targets have been identified that provide great potential for the development of new cancer diagnostics and therapies. Four key features of cancer cells distinguish them from their normal counterparts: loss of cell-cycle regulation, loss of control over invasion and metastasis, failure of apoptotic mechanisms, and bypass of senescence. This review examines our understanding of the bypass of senescence and the process of immortalization during carcinogenesis. In addition, the realistic opportunities for telomerase in cancer diagnostics and the challenges faced in clinical trial design for telomerase therapeutics are discussed.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Evans, Professor Jeff and Keith, Professor Nicol |
Authors: | Keith, W.N., Evans, T.R.J., and Glasspool, R.M. |
Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RB Pathology |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | Journal of Pathology |
ISSN: | 0022-3417 |
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