The comparative genomics and phylogenomics of Leishmania amazonensis parasite

Tschoeke, D. A. et al. (2014) The comparative genomics and phylogenomics of Leishmania amazonensis parasite. Evolutionary Bioinformatics, 2014(8), pp. 131-153. (doi: 10.4137/EBO.S13759)

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Abstract

Leishmaniasis is an infectious disease caused by Leishmania species. Leishmania amazonensis is a New World Leishmania species belonging to the Mexicana complex, which is able to cause all types of leishmaniasis infections. The L. amazonensis reference strain MHOM/BR/1973/M2269 was sequenced identifying 8,802 codifying sequences (CDS), most of them of hypothetical function. Comparative analysis using six Leishmania species showed a core set of 7,016 orthologs. L. amazonensis and Leishmania mexicana share the largest number of distinct orthologs, while Leishmania braziliensis presented the largest number of inparalogs. Additionally, phylogenomic analysis confirmed the taxonomic position for L. amazonensis within the “Mexicana complex”, reinforcing understanding of the split of New and Old World Leishmania. Potential non-homologous isofunctional enzymes (NISE) were identified between L. amazonensis and Homo sapiens that could provide new drug targets for development.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Dickens, Dr Nicholas and Mottram, Professor Jeremy
Authors: Tschoeke, D. A., Nunes, G. L., Jardim, R., Lima, J., Dumaresq, A. S.R., Gomes, M. R., de Mattos Pereira, L., Loureiro, D. R., Stoco, P. H., de Matos Guedes, H., de Miranda, A., Ruiz, J., Pitaluga, A., Silva, F. P., Probst, C. M., Dickens, N. J., Mottram, J. C., Grisard, E., and Davila, A. M.R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Evolutionary Bioinformatics
Publisher:Libertas Academica
ISSN:1176-9343
ISSN (Online):1176-9343
Copyright Holders:Copyright © 2014 The Authors
First Published:First published in Evolutionary Bioinformatics 2014(8):131-153
Publisher Policy:Reproduced under a Creative Commons License
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
371796The Wellcome Centre for Molecular Parasitology ( Core Support )Andrew WatersWellcome Trust (WELLCOME)085349/Z/08/ZIII - PARASITOLOGY
371798The Wellcome Centre for Molecular Parasitology ( Core Support )Andrew WatersWellcome Trust (WELLCOME)085349/B/08/ZIII - PARASITOLOGY