Downey, M.G., Going, J.J., Stuart, R.C. and Keith, W.N. (2001) Expression of telomerase RNA in oesophageal and oral cancer. Journal of Oral Pathology and Medicine, 30(10), pp. 577-581. (doi: 10.1034/j.1600-0714.2001.301001.x)
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Publisher's URL: http://dx.doi.org/10.1034/j.1600-0714.2001.301001.x
Abstract
Background: Telomerase is detectable in 85% of cancers, but is largely repressed in normal tissues. Human telomerase RNA (hTR) inhibition is a promising anti-cancer strategy, but requires differential expression between malignant and normal tissue.<br/><br/> Method: Archival paraffin sections from 48 oral squamous cell carcinomas (SCC) (23 floor of mouth, 25 tongue) and 56 oesophageal carcinomas (41 SCC, 15 adenocarcinomas) were evaluated for hTR expression using a radiolabelled riboprobe. Results were compared with expression in controls and adjacent histologically normal tissue. Statistical analysis was by the chi<sup>2</sup> test.<br/><br/> Results: hTR was detectable in 76% of oral SCC overall (floor of mouth 65%, tongue 88%, P = 0.61), and in 54% of oesophageal cancers (SCC 51%, adenocarcinoma 60%, P = 0.56). Detectable hTR expression was significantly more frequent in oral SCC than oesophageal SCC (P = 0.01). hTR expression was only detected in normal tissue at low levels in basal squamous epithelium. There was agreement of hTR expression between 8/9 surgically excised carcinomas and their initial diagnostic biopsies. <br/><br/>Conclusion: Tumour-specific hTR expression confirms hTR inhibition as a possible therapeutic strategy in some if not all oesophageal and oral cancers. Generally concordant hTR status between biopsy and resection suggest that biopsy may have a role in selecting candidates for telomerase inhibition therapy.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Going, Dr James and Keith, Professor Nicol |
Authors: | Downey, M.G., Going, J.J., Stuart, R.C., and Keith, W.N. |
Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) Q Science > QH Natural history > QH426 Genetics |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | Journal of Oral Pathology and Medicine |
ISSN: | 0904-2512 |
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