Prefrontal control over motor cortex cycles at beta-frequency during movement inhibition

Picazio, S., Veniero, D., Ponzo, V., Caltagirone, C., Gross, J. , Thut, G. and Koch, G. (2014) Prefrontal control over motor cortex cycles at beta-frequency during movement inhibition. Current Biology, 24(24), pp. 2940-2945. (doi:10.1016/j.cub.2014.10.043) (PMID:25484293) (PMCID:PMC4274313)

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Abstract

A fully adapted behavior requires maximum efficiency to inhibit processes in the motor domain [ 1 ]. Although a number of cortical and subcortical brain regions have been implicated, converging evidence suggests that activation of right inferior frontal gyrus (r-IFG) and right presupplementary motor area (r-preSMA) is crucial for successful response inhibition [ 2, 3 ]. However, it is still unknown how these prefrontal areas convey the necessary signal to the primary motor cortex (M1), the cortical site where the final motor plan eventually has to be inhibited or executed. On the basis of the widely accepted view that brain oscillations are fundamental for communication between neuronal network elements [ 4–6 ], one would predict that the transmission of these inhibitory signals within the prefrontal-central networks (i.e., r-IFG/M1 and/or r-preSMA/M1) is realized in rapid, periodic bursts coinciding with oscillatory brain activity at a distinct frequency. However, the dynamics of corticocortical effective connectivity has never been directly tested on such timescales. By using double-coil transcranial magnetic stimulation (TMS) and electroencephalography (EEG) [ 7, 8 ], we assessed instantaneous prefrontal-to-motor cortex connectivity in a Go/NoGo paradigm as a function of delay from (Go/NoGo) cue onset. In NoGo trials only, the effects of a conditioning prefrontal TMS pulse on motor cortex excitability cycled at beta frequency, coinciding with a frontocentral beta signature in EEG. This establishes, for the first time, a tight link between effective cortical connectivity and related cortical oscillatory activity, leading to the conclusion that endogenous (top-down) inhibitory motor signals are transmitted in beta bursts in large-scale cortical networks for inhibitory motor control.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Thut, Professor Gregor and Gross, Professor Joachim and Veniero, Dr Domenica
Authors: Picazio, S., Veniero, D., Ponzo, V., Caltagirone, C., Gross, J., Thut, G., and Koch, G.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Current Biology
Publisher:Cell Press
ISSN:0960-9822
ISSN (Online):1879-0445
Copyright Holders:Copyright © 2014 The Authors
First Published:First published in Current Biology 24(24:2940-2945
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
597911Natural and modulated neural communication: State-dependent decoding and driving of human Brain OscillationsGregor ThutWellcome Trust (WELLCOME)098434/Z/12/ZINP - CENTRE FOR COGNITIVE NEUROIMAGING
597051Natural and modulated neural communication: State-dependent decoding and driving of human Brain Oscillations.Joachim GrossWellcome Trust (WELLCOME)098433/Z/12/ZINP - CENTRE FOR COGNITIVE NEUROIMAGING