Protein-protein interactions at G-protein-coupled receptors

Milligan, G. and White, J. H. (2001) Protein-protein interactions at G-protein-coupled receptors. Trends in Pharmacological Sciences, 22(10), pp. 513-518. (doi: 10.1016/S0165-6147(00)01801-0)

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Publisher's URL: http://dx.doi.org/10.1016/S0165-6147(00)01801-0

Abstract

The basic module of signal transduction that involves G-protein-coupled receptors is usually portrayed as comprising a receptor, a heterotrimeric G protein and an effector. It is now well established that regulated interactions between receptors and arrestins, and between G proteins and regulators of G-protein signalling alter the effectiveness and kinetics of information transfer. However, more recent studies have begun to identify a host of other proteins that interact selectively with individual receptors at both the intracellular and extracellular face of the membrane. Although the functional relevance of many of these interactions is only beginning to be understood, current information indicates that these interactions might determine receptor properties, such as cellular compartmentalization or signal selection, and can promote protein scaffolding into complexes that integrate function.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Milligan, Professor Graeme
Authors: Milligan, G., and White, J. H.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Trends in Pharmacological Sciences
Publisher:Elsevier
ISSN:0165-6147
ISSN (Online):1873-3735
Published Online:26 September 2001

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