Kioumourtzoglou, D., Sadler, J. B.A., Black, H. L., Berends, R., Wellburn, C., Bryant, N. J. and Gould, G. W. (2014) Studies of the regulated assembly of SNARE complexes in adipocytes. Biochemical Society Transactions, 42(5), pp. 1396-1400. (doi: 10.1042/BST20140114)
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Abstract
Insulin plays a fundamental role in whole-body glucose homeostasis. Central to this is the hormone's ability to rapidly stimulate the rate of glucose transport into adipocytes and muscle cells [1]. Upon binding its receptor, insulin stimulates an intracellular signalling cascade that culminates in redistribution of glucose transporter proteins, specifically the GLUT4 isoform, from intracellular stores to the plasma membrane, a process termed ‘translocation’ [1,2]. This is an example of regulated membrane trafficking [3], a process that also underpins other aspects of physiology in a number of specialized cell types, for example neurotransmission in brain/neurons and release of hormone-containing vesicles from specialized secretory cells such as those found in pancreatic islets. These processes invoke a number of intriguing biological questions as follows. How is the machinery involved in these membrane trafficking events mobilized in response to a stimulus? How do the signalling pathways that detect the external stimulus interface with the trafficking machinery? Recent studies of insulin-stimulated GLUT4 translocation offer insight into such questions. In the present paper, we have reviewed these studies and draw parallels with other regulated trafficking systems.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Sadler, Miss Jessica and Kioumourtzoglou, Mr Dimitrios and Gould, Professor Gwyn and Bryant, Dr Nia and Berends, Dr Rebecca |
Authors: | Kioumourtzoglou, D., Sadler, J. B.A., Black, H. L., Berends, R., Wellburn, C., Bryant, N. J., and Gould, G. W. |
College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
Journal Name: | Biochemical Society Transactions |
Publisher: | Portland Press |
ISSN: | 0300-5127 |
ISSN (Online): | 1470-8752 |
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