Fibroblasts derived from long-lived insulin receptor substrate 1 null mice are not resistant to multiple forms of stress

Page, M. M., Sinclair, A., Robb, E. L., Stuart, J. A., Withers, D. J. and Selman, C. (2014) Fibroblasts derived from long-lived insulin receptor substrate 1 null mice are not resistant to multiple forms of stress. Aging Cell, 13(5), pp. 962-964. (doi: 10.1111/acel.12255) (PMID:25059507) (PMCID:PMC4331740)

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Abstract

Reduced signalling through the insulin/insulin-like growth factor-1 signalling (IIS) pathway is a highly conserved lifespan determinant in model organisms. The precise mechanism underlying the effects of the IIS on lifespan and health is currently unclear, although cellular stress resistance may be important. We have previously demonstrated that mice globally lacking insulin receptor substrate 1 (Irs1−/−) are long-lived and enjoy a greater period of their life free from age-related pathology compared with wild-type (WT) controls. In this study, we show that primary dermal fibroblasts and primary myoblasts derived from Irs1−/− mice are no more resistant to a range of oxidant and nonoxidant chemical stressors than cells derived from WT mice.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Selman, Professor Colin and Sinclair, Miss Amy
Authors: Page, M. M., Sinclair, A., Robb, E. L., Stuart, J. A., Withers, D. J., and Selman, C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Aging Cell
Publisher:Anatomical Society and John Wiley & Sons Ltd.
ISSN:1474-9718
ISSN (Online):1474-9726
Copyright Holders:Copyright © 2014 The Authors
First Published:First published in Aging Cell 13(5):962-964
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
638451Dissecting the mechanisms underlying lifespan extension in insulin signalling mutant miceColin SelmanBiotechnology and Biological Sciences Research Council (BBSRC)BB/H012850/2RI BIODIVERSITY ANIMAL HEALTH & COMPMED