Confocal microscopy for structure and realtime pharmacology in blood vessels

McGrath, J.C. , Arribas, S., Daly, C.J. and Gordon, J.F. (1995) Confocal microscopy for structure and realtime pharmacology in blood vessels. Journal of Human Hypertension, 9(8), pp. 645-647.

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The structure and composition of living small blood vessels can be studied in great detail in three dimensions using confocal microscopy. Individual cells and their components can be visualised by vital dyes for the nucleus, cytoplasm or extracellular space. Specific ligands can then localise individual components such as membrane receptors with great precision. Cell function is unaffected, allowing the study, in real time, of the changing relation and contribution to vascular contraction or dilatation of different cell types particularly smooth muscle, endothelium and adventitia. This allows not only visualisation but quantification, using image analysis software. These techniques will be of particular value in assessing the contribution of form to function in pathological situations such as vascular remodelling in hypertension.

Item Type:Articles
Glasgow Author(s) Enlighten ID:McGrath, Professor John and Daly, Professor Craig
Authors: McGrath, J.C., Arribas, S., Daly, C.J., and Gordon, J.F.
College/School:College of Medical Veterinary and Life Sciences > School of Life Sciences
Journal Name:Journal of Human Hypertension
Publisher:Nature Publishing Group
ISSN (Online):1476-5527
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