Coggins, J.R., Abell, C., Evan, L.B., Frederickson, M., Robinson, D.A., Roszak, A.W. and Lapthorn, A.P. (2003) Experiences with the Shikimate-pathway enzymes as targets for rational drug design. Biochemical Society Transactions, 31(3), pp. 548-552.
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Abstract
The background and current context of work on the shikimate-pathway enzymes as potential targets for anti-bacterial, anti-fungal and anti-parasitic drugs is reviewed. Recent work on the third enzyme of the pathway, dehydroquinase, which occurs in two structurally and mechanistically distinct forms, is used to illustrate the present state of studies into rational drug design.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Lapthorn, Dr Adrian and Coggins, Professor John and Roszak, Dr Aleksander |
| Authors: | Coggins, J.R., Abell, C., Evan, L.B., Frederickson, M., Robinson, D.A., Roszak, A.W., and Lapthorn, A.P. |
| Subjects: | Q Science > QH Natural history > QH345 Biochemistry |
| College/School: | College of Medical Veterinary and Life Sciences |
| Journal Name: | Biochemical Society Transactions |
| ISSN: | 0300-5127 |
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