A finite strain nonlinear human mitral valve model with fluid structure interaction

Gao, H. , Ma, X., Nan, Q., Berry, C. , Griffith, B. E. and Luo, X. (2014) A finite strain nonlinear human mitral valve model with fluid structure interaction. International Journal for Numerical Methods in Biomedical Engineering, 30(12), pp. 1597-1613. (doi:10.1002/cnm.2691) (PMID:25319496) (PMCID:PMC4278556)

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Abstract

A simulated human mitral valve under a physiological pressure loading is developed using a hybrid finite element immersed boundary method, which incorporates experimentally based constitutive laws in a three-dimensional fluid-structure interaction framework. A transversely isotropic material constitutive model is used for characterizing the mechanical behaviour of the mitral valve tissue based on recent mechanical tests of healthy human mitral leaflets. Our results show good agreement, in terms of the flow rate and the closing and opening configurations, with the measurements from the magnetic resonance images. The stresses in the anterior leaflet are found to be higher than those in the posterior leaflet, and concentrated around the annulus trigons and free edges of the valve leaflets. Those areas are located where the leaflet has the highest curvature. Effects of the chordae tendineae in the material model are studied and the results show that these chordae play an important role in providing a secondary orifice for the flow when valve opens. Although there are some discrepancies to be overcome in future works, our simulations show that the developed computational model is promising in mimicking the in vivo mitral valve dynamics and providing important information that are not obtainable by in vivo measurements. This article is protected by copyright. All rights reserved.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Luo, Professor Xiaoyu and Ma, Miss Xingshuang and Griffith, Dr Boyce and Gao, Dr Hao and Berry, Professor Colin
Authors: Gao, H., Ma, X., Nan, Q., Berry, C., Griffith, B. E., and Luo, X.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Science and Engineering > School of Mathematics and Statistics > Mathematics
Journal Name:International Journal for Numerical Methods in Biomedical Engineering
Publisher:John Wiley & Sons Ltd.
ISSN:2040-7939
ISSN (Online):2040-7947
Copyright Holders:Copyright © 2014 The Authors
First Published:First published in International Journal for Numerical Methods in Biomedical Engineering 30(12):1597-1613
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
560111Finite element-immersed boundary method and its application to mitral valvesXiaoyu LuoEngineering & Physical Sciences Research Council (EPSRC)EP/I029990/1M&S - MATHEMATICS