Action potential conduction velocity is increased by raised intracellular camp in the intact rat heart via a CaMKII mediated pathway

Campbell, A. S., Burton, F. L., Baillie, G. and Smith, G. L. (2014) Action potential conduction velocity is increased by raised intracellular camp in the intact rat heart via a CaMKII mediated pathway. In: 58th Annual Meeting of the Biophysical-Society, San Francisco CA, USA, 15-19 Feb 2014, 119a.

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Publisher's URL: http://www.cell.com/biophysj/abstract/S0006-3495(13)01951-6

Abstract

This study examines the changes in ventricular conduction (CV) and action potential (AP) shape in isolated rat hearts during prolonged exposure to raised intracellular cAMP. Adult male Wistar rats (300-500g) were euthanized and hearts removed and Langendorff perfused with modified Tyrode's solution at 37oC. CV was recorded using custom electrodes placed on the epicardial surface of the left ventricle, which was paced continuously at 8HZ. The delay between the AP wavefront reaching two sequential sets of recording electrodes was used to calculate the CV. Annabel S. Campbell, Francis L. Burton, George S. Baillie, Godfrey L. Smith

Item Type:Conference Proceedings
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Smith, Professor Godfrey and Baillie, Professor George and Burton, Dr Francis
Authors: Campbell, A. S., Burton, F. L., Baillie, G., and Smith, G. L.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
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